TY - JOUR

T1 - Trends in survival of epithelial ovarian/tubal cancer by histology and socioeconomic status in Denmark 1996–2017

AU - Faber, M. T.

AU - Horsbøl, T. A.

AU - Baandrup, L.

AU - Dalton, S. O.

AU - Kjaer, S. K.

N1 - Publisher Copyright: © 2021 Elsevier Inc.

PY - 2022

Y1 - 2022

N2 - Objectives: To examine time trends in ovarian/tubal cancer relative survival, excess mortality, and all-cause mortality for different histological types and levels of socioeconomic position. Methods: Women with ovarian/tubal cancer diagnosed 1996–2017 were identified in the Danish Cancer Registry (n = 11,755). Age-standardized 5-year relative survival over time was estimated by histology, socioeconomic status, and stage. Furthermore, 5-year excess mortality rate ratios (EMRR) according to calendar time for all categories of histology and socioeconomic status were calculated using a Poisson regression model. Finally, all-cause mortality by histology and socioeconomic status was estimated in multivariate Cox proportional hazards regression models. Results: Statistically significant improvements in 5-year relative survival occurred for all histological types over time except mucinous tumors (5-year EMRR, localized: 0.92 (95% CI: 0.71–1.16); advanced: 0.96 (95% CI: 0.85–1.08). Increase in relative survival over time and corresponding decrease in excess mortality was observed for all categories of socioeconomic status except for women with localized disease in the lowest income group (5-year EMRR = 0.91 (95% CI:0.76–1.10)). The impact of histology and socioeconomic status on all-cause mortality depended on time since diagnosis. Among the socioeconomic factors, especially low educational level and living alone were associated with increased all-cause mortality, particularly in the first year after diagnosis. Conclusions: Ovarian/tubal cancer survival generally increased over time across histological types and socioeconomic factors. However, the lack of improvement for mucinous tumors needs further research. Additionally, the results for women with low income and education shows that continued focus on social equality in survival is necessary.

AB - Objectives: To examine time trends in ovarian/tubal cancer relative survival, excess mortality, and all-cause mortality for different histological types and levels of socioeconomic position. Methods: Women with ovarian/tubal cancer diagnosed 1996–2017 were identified in the Danish Cancer Registry (n = 11,755). Age-standardized 5-year relative survival over time was estimated by histology, socioeconomic status, and stage. Furthermore, 5-year excess mortality rate ratios (EMRR) according to calendar time for all categories of histology and socioeconomic status were calculated using a Poisson regression model. Finally, all-cause mortality by histology and socioeconomic status was estimated in multivariate Cox proportional hazards regression models. Results: Statistically significant improvements in 5-year relative survival occurred for all histological types over time except mucinous tumors (5-year EMRR, localized: 0.92 (95% CI: 0.71–1.16); advanced: 0.96 (95% CI: 0.85–1.08). Increase in relative survival over time and corresponding decrease in excess mortality was observed for all categories of socioeconomic status except for women with localized disease in the lowest income group (5-year EMRR = 0.91 (95% CI:0.76–1.10)). The impact of histology and socioeconomic status on all-cause mortality depended on time since diagnosis. Among the socioeconomic factors, especially low educational level and living alone were associated with increased all-cause mortality, particularly in the first year after diagnosis. Conclusions: Ovarian/tubal cancer survival generally increased over time across histological types and socioeconomic factors. However, the lack of improvement for mucinous tumors needs further research. Additionally, the results for women with low income and education shows that continued focus on social equality in survival is necessary.

KW - Histological types

KW - Ovarian cancer

KW - Socioeconomic status

KW - Survival

KW - Tubal cancer

UR - http://www.scopus.com/inward/record.url?scp=85118837561&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2021.10.091

DO - 10.1016/j.ygyno.2021.10.091

M3 - Journal article

C2 - 34763941

AN - SCOPUS:85118837561

VL - 164

SP - 98

EP - 104

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -