Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020: A Multicohort Collaboration

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Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020 : A Multicohort Collaboration. / Tusch, Erich; Ryom, Lene; Pelchen-Matthews, Annegret; Mocroft, Amanda; Elbirt, Daniel; Oprea, Cristiana; Günthard, Huldrych F.; Staehelin, Cornelia; Zangerle, Robert; Suarez, Isabelle; Vehreschild, Jörg Janne; Wit, Ferdinand; Menozzi, Marianna; Monforte, Antonella d'Arminio; Spagnuolo, Vincenzo; Pradier, Christian; Carlander, Christina; Suanzes, Paula; Wasmuth, Jan-Christian; Carr, Andrew; Petoumenos, Kathy; Borgans, Frauke; Bonnet, Fabrice; De Wit, Stephane; El-Sadr, Wafaa; Neesgaard, Bastian; Jaschinski, Nadine; Greenberg, Lauren; Hosein, Sean R.; Gallant, Joel; Vannappagari, Vani; Young, Lital; Sabin, Caroline; Lundgren, Jens; Peters, Lars; Reekie, Joanne; D:A:D cohort study ; RESPOND Cohort Collaboration.

I: Clinical Infectious Diseases, 26.04.2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, HF, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, JJ, Wit, F, Menozzi, M, Monforte, ADA, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, J-C, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, SR, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L, Reekie, J, D:A:D cohort study & RESPOND Cohort Collaboration 2024, 'Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020: A Multicohort Collaboration', Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciae228

APA

Tusch, E., Ryom, L., Pelchen-Matthews, A., Mocroft, A., Elbirt, D., Oprea, C., Günthard, H. F., Staehelin, C., Zangerle, R., Suarez, I., Vehreschild, J. J., Wit, F., Menozzi, M., Monforte, A. DA., Spagnuolo, V., Pradier, C., Carlander, C., Suanzes, P., Wasmuth, J-C., ... RESPOND Cohort Collaboration (2024). Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020: A Multicohort Collaboration. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciae228

Vancouver

Tusch E, Ryom L, Pelchen-Matthews A, Mocroft A, Elbirt D, Oprea C o.a. Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020: A Multicohort Collaboration. Clinical Infectious Diseases. 2024 apr. 26. https://doi.org/10.1093/cid/ciae228

Author

Tusch, Erich ; Ryom, Lene ; Pelchen-Matthews, Annegret ; Mocroft, Amanda ; Elbirt, Daniel ; Oprea, Cristiana ; Günthard, Huldrych F. ; Staehelin, Cornelia ; Zangerle, Robert ; Suarez, Isabelle ; Vehreschild, Jörg Janne ; Wit, Ferdinand ; Menozzi, Marianna ; Monforte, Antonella d'Arminio ; Spagnuolo, Vincenzo ; Pradier, Christian ; Carlander, Christina ; Suanzes, Paula ; Wasmuth, Jan-Christian ; Carr, Andrew ; Petoumenos, Kathy ; Borgans, Frauke ; Bonnet, Fabrice ; De Wit, Stephane ; El-Sadr, Wafaa ; Neesgaard, Bastian ; Jaschinski, Nadine ; Greenberg, Lauren ; Hosein, Sean R. ; Gallant, Joel ; Vannappagari, Vani ; Young, Lital ; Sabin, Caroline ; Lundgren, Jens ; Peters, Lars ; Reekie, Joanne ; D:A:D cohort study ; RESPOND Cohort Collaboration. / Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020 : A Multicohort Collaboration. I: Clinical Infectious Diseases. 2024.

Bibtex

@article{359ac93e8da24d66846916c0fba8840d,
title = "Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020: A Multicohort Collaboration",
abstract = "BACKGROUND: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020.METHODS: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time.RESULTS: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period.CONCLUSION: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.",
author = "Erich Tusch and Lene Ryom and Annegret Pelchen-Matthews and Amanda Mocroft and Daniel Elbirt and Cristiana Oprea and G{\"u}nthard, {Huldrych F.} and Cornelia Staehelin and Robert Zangerle and Isabelle Suarez and Vehreschild, {J{\"o}rg Janne} and Ferdinand Wit and Marianna Menozzi and Monforte, {Antonella d'Arminio} and Vincenzo Spagnuolo and Christian Pradier and Christina Carlander and Paula Suanzes and Jan-Christian Wasmuth and Andrew Carr and Kathy Petoumenos and Frauke Borgans and Fabrice Bonnet and {De Wit}, Stephane and Wafaa El-Sadr and Bastian Neesgaard and Nadine Jaschinski and Lauren Greenberg and Hosein, {Sean R.} and Joel Gallant and Vani Vannappagari and Lital Young and Caroline Sabin and Jens Lundgren and Lars Peters and Joanne Reekie and {D:A:D cohort study} and {RESPOND Cohort Collaboration}",
note = "{\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.",
year = "2024",
month = apr,
day = "26",
doi = "10.1093/cid/ciae228",
language = "English",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020

T2 - A Multicohort Collaboration

AU - Tusch, Erich

AU - Ryom, Lene

AU - Pelchen-Matthews, Annegret

AU - Mocroft, Amanda

AU - Elbirt, Daniel

AU - Oprea, Cristiana

AU - Günthard, Huldrych F.

AU - Staehelin, Cornelia

AU - Zangerle, Robert

AU - Suarez, Isabelle

AU - Vehreschild, Jörg Janne

AU - Wit, Ferdinand

AU - Menozzi, Marianna

AU - Monforte, Antonella d'Arminio

AU - Spagnuolo, Vincenzo

AU - Pradier, Christian

AU - Carlander, Christina

AU - Suanzes, Paula

AU - Wasmuth, Jan-Christian

AU - Carr, Andrew

AU - Petoumenos, Kathy

AU - Borgans, Frauke

AU - Bonnet, Fabrice

AU - De Wit, Stephane

AU - El-Sadr, Wafaa

AU - Neesgaard, Bastian

AU - Jaschinski, Nadine

AU - Greenberg, Lauren

AU - Hosein, Sean R.

AU - Gallant, Joel

AU - Vannappagari, Vani

AU - Young, Lital

AU - Sabin, Caroline

AU - Lundgren, Jens

AU - Peters, Lars

AU - Reekie, Joanne

AU - D:A:D cohort study

AU - RESPOND Cohort Collaboration

N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

PY - 2024/4/26

Y1 - 2024/4/26

N2 - BACKGROUND: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020.METHODS: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time.RESULTS: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period.CONCLUSION: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.

AB - BACKGROUND: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020.METHODS: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time.RESULTS: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period.CONCLUSION: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.

U2 - 10.1093/cid/ciae228

DO - 10.1093/cid/ciae228

M3 - Journal article

C2 - 38663013

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

ER -

ID: 395580851