Treatment Patterns in Danish Patients with Atopic Dermatitis Before and After Hospital Referral
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Introduction: A number of treatments for atopic dermatitis (AD) are available; however, long-term treatment patterns and healthcare consumption in patients with AD are poorly described. Methods: We conducted a registry-based longitudinal drug utilization study among Danish patients with AD that were referred to their first-ever visit at hospital-based dermatology clinics. Their first visit was in the period between 1 January 2005 and 31 December 2012, and patients were followed up to 5 years after their first visit. Results: In total, 8213 people with a first-time hospital dermatologist contact for AD were included in the study (3514 aged 0–9 years, 1501 aged 10–19 years, 3198 aged 20 years or older). At first visit, a baseline history of moderately potent topical corticosteroid (TCS) use was seen among 46.6% of children (0–9 years), whereas potent or very potent TCS use was more frequently among older individuals (e.g., 51.1% and 25.6% of people aged 50 years or older had used potent and very potent TCS, respectively). The median (interquartile range) annual number of visits to general practitioners was 4 (2–7) for children and 5 (2–8) for adults, in the 12 months prior to referral. Three years after referral, these numbers had decreased to 2 (1–4) and 3 (1–6), respectively. In the first year after referral, 6% of patients were prescribed systemic corticosteroids, whereas other systemic therapies were used in 5% or less. Conclusions: After referral, low proportions of patients received systemic treatment, or potent TCS. These findings highlight considerable differences in treatment patterns between general practitioners and private practice dermatologists, compared with hospital-based dermatologists, and emphasize the need for better adherence to evidence-based treatment guidelines.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Dermatology and Therapy |
| Vol/bind | 11 |
| Udgave nummer | 2 |
| Sider (fra-til) | 499-512 |
| Antal sider | 14 |
| ISSN | 2193-8210 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
The study and the journal?s rapid service fee was supported by Eli Lilly and Company. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Dr. Alexander Egeberg has received research funding from Pfizer, Eli Lilly, the Danish National Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation, and honoraria as consultant and/or speaker from AbbVie, Almirall, Leo Pharma, Samsung Bioepis Co., Ltd., Pfizer, UCB, Eli Lilly and Company, Novartis, Galderma, Dermavant, Bristol-Myers Squibb, and Janssen Pharmaceuticals. Dr. Jacob Thyssen has attended advisory boards for Eli Lilly & Co, Pfizer, Abbvie, LEO Pharma, and Sanofi-Genzyme; received speaker honorarium from LEO Pharma, Regeneron, Abbvie and Sanofi-Genzyme and been an investigator for LEO Pharma, Eli Lilly & Co, Abbvie, Pfizer, and Sanofi-Genzyme. Dr. Jashin Wu is or has been an investigator, consultant, or speaker for AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Dermavant, Dermira, Dr. Reddy?s Laboratories, Eli Lilly, Janssen, LEO Pharma, Novartis, Regeneron, Sanofi Genzyme, Sun Pharmaceutical, UCB, Valeant Pharmaceuticals North America LLC. Drs. Evangeline Pierce and Jorge Terres are currently employed by Eli Lilly and Company. Approval from an ethics committee is not required for register studies in Denmark (Danish law: Lov om videnskabsetisk behandling af sundhedsvidenskabelige forskningsprojekter, ? 14, stk. 2). The datasets generated during and/or analyzed during the current study are not publicly available due to Danish law. The repository can only be accessed by authorized researchers.
Funding Information:
The study and the journal’s rapid service fee was supported by Eli Lilly and Company.
Funding Information:
Dr. Alexander Egeberg has received research funding from Pfizer, Eli Lilly, the Danish National Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation, and honoraria as consultant and/or speaker from AbbVie, Almirall, Leo Pharma, Samsung Bioepis Co., Ltd., Pfizer, UCB, Eli Lilly and Company, Novartis, Galderma, Dermavant, Bristol-Myers Squibb, and Janssen Pharmaceuticals. Dr. Jacob Thyssen has attended advisory boards for Eli Lilly & Co, Pfizer, Abbvie, LEO Pharma, and Sanofi-Genzyme; received speaker honorarium from LEO Pharma, Regeneron, Abbvie and Sanofi-Genzyme and been an investigator for LEO Pharma, Eli Lilly & Co, Abbvie, Pfizer, and Sanofi-Genzyme. Dr. Jashin Wu is or has been an investigator, consultant, or speaker for AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Dermavant, Dermira, Dr. Reddy’s Laboratories, Eli Lilly, Janssen, LEO Pharma, Novartis, Regeneron, Sanofi Genzyme, Sun Pharmaceutical, UCB, Valeant Pharmaceuticals North America LLC. Drs. Evangeline Pierce and Jorge Terres are currently employed by Eli Lilly and Company.
Publisher Copyright:
© 2021, The Author(s).
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