Translation attenuation mechanism in unfolded protein response
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
Standard
Translation attenuation mechanism in unfolded protein response. / Trusina, Ala; Papa, Feroz; Tang, Chao.
Evolution from Cellular to Social Scales. red. / Arne Skjeltorp; Arne Skjeltorp; Alexander Belushkin. 2008. s. 83-90 (NATO Science for Peace and Security Series B: Physics and Biophysics).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - CHAP
T1 - Translation attenuation mechanism in unfolded protein response
AU - Trusina, Ala
AU - Papa, Feroz
AU - Tang, Chao
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.
AB - Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.
KW - Stress response
KW - Translational attenuation
KW - Unfolded protein response
KW - UPR
UR - http://www.scopus.com/inward/record.url?scp=77949445259&partnerID=8YFLogxK
U2 - 10.1007/978-1-4020-8761-5-6
DO - 10.1007/978-1-4020-8761-5-6
M3 - Book chapter
AN - SCOPUS:77949445259
SN - 9781402087608
T3 - NATO Science for Peace and Security Series B: Physics and Biophysics
SP - 83
EP - 90
BT - Evolution from Cellular to Social Scales
A2 - Skjeltorp, Arne
A2 - Skjeltorp, Arne
A2 - Belushkin, Alexander
ER -
ID: 229440002