Transcriptomics age acceleration in prolonged treated HIV infection

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Standard

Transcriptomics age acceleration in prolonged treated HIV infection. / Mikaeloff, Flora; Gelpi, Marco; Escos, Alejandra; Knudsen, Andreas D.; Høgh, Julie; Benfield, Thomas; de Magalhães, João Pedro; Nielsen, Susanne D.; Neogi, Ujjwal.

I: Aging Cell, Bind 22, Nr. 10, e13951, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mikaeloff, F, Gelpi, M, Escos, A, Knudsen, AD, Høgh, J, Benfield, T, de Magalhães, JP, Nielsen, SD & Neogi, U 2023, 'Transcriptomics age acceleration in prolonged treated HIV infection', Aging Cell, bind 22, nr. 10, e13951. https://doi.org/10.1111/acel.13951

APA

Mikaeloff, F., Gelpi, M., Escos, A., Knudsen, A. D., Høgh, J., Benfield, T., de Magalhães, J. P., Nielsen, S. D., & Neogi, U. (2023). Transcriptomics age acceleration in prolonged treated HIV infection. Aging Cell, 22(10), [e13951]. https://doi.org/10.1111/acel.13951

Vancouver

Mikaeloff F, Gelpi M, Escos A, Knudsen AD, Høgh J, Benfield T o.a. Transcriptomics age acceleration in prolonged treated HIV infection. Aging Cell. 2023;22(10). e13951. https://doi.org/10.1111/acel.13951

Author

Mikaeloff, Flora ; Gelpi, Marco ; Escos, Alejandra ; Knudsen, Andreas D. ; Høgh, Julie ; Benfield, Thomas ; de Magalhães, João Pedro ; Nielsen, Susanne D. ; Neogi, Ujjwal. / Transcriptomics age acceleration in prolonged treated HIV infection. I: Aging Cell. 2023 ; Bind 22, Nr. 10.

Bibtex

@article{0dc730bf8d6749208e964fffa664683b,

title = "Transcriptomics age acceleration in prolonged treated HIV infection",

abstract = "Biological aging in people with HIV (PWH) with prolonged successful antiretroviral therapy (ART) is convoluted and poorly defined. Here, we aimed to investigate the transcriptomics age estimator (TAE) in a cohort of 178 PWH on prolonged successful ART with immune reconstitution and viral suppression from the Copenhagen Comorbidity (COCOMO) cohort. We also used 143 clinical, demographical, and lifestyle factors to identify the confounders potentially responsible or associated with age acceleration. Among the PWH, 43% had an accelerated aging process (AAP), and 21% had decelerated aging process (DAP). DAP is linked with older age, European ancestry, and higher use of tenofovir disoproxil/alafenamide fumarate. A directionally class-based gene set enrichment analysis identified the upregulation of inflammatory pathways (e.g., cytokine and Retinoic acid-inducible gene I (RIG-I)-like receptor signaling pathways) and immune response like T-cell receptor signaling, antigen processing, and presentation in AAP and the downregulation of metabolic processes like oxidative phosphorylation, pyruvate metabolism.",

keywords = "biological aging, transcriptomics aging clock, treated HIV infection",

author = "Flora Mikaeloff and Marco Gelpi and Alejandra Escos and Knudsen, {Andreas D.} and Julie H{\o}gh and Thomas Benfield and {de Magalh{\~a}es}, {Jo{\~a}o Pedro} and Nielsen, {Susanne D.} and Ujjwal Neogi",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.",

year = "2023",

doi = "10.1111/acel.13951",

language = "English",

volume = "22",

journal = "Aging Cell",

issn = "1474-9718",

publisher = "Wiley-Blackwell",

number = "10",

}

RIS

TY - JOUR

T1 - Transcriptomics age acceleration in prolonged treated HIV infection

AU - Mikaeloff, Flora

AU - Gelpi, Marco

AU - Escos, Alejandra

AU - Knudsen, Andreas D.

AU - Høgh, Julie

AU - Benfield, Thomas

AU - de Magalhães, João Pedro

AU - Nielsen, Susanne D.

AU - Neogi, Ujjwal

PY - 2023

Y1 - 2023

N2 - Biological aging in people with HIV (PWH) with prolonged successful antiretroviral therapy (ART) is convoluted and poorly defined. Here, we aimed to investigate the transcriptomics age estimator (TAE) in a cohort of 178 PWH on prolonged successful ART with immune reconstitution and viral suppression from the Copenhagen Comorbidity (COCOMO) cohort. We also used 143 clinical, demographical, and lifestyle factors to identify the confounders potentially responsible or associated with age acceleration. Among the PWH, 43% had an accelerated aging process (AAP), and 21% had decelerated aging process (DAP). DAP is linked with older age, European ancestry, and higher use of tenofovir disoproxil/alafenamide fumarate. A directionally class-based gene set enrichment analysis identified the upregulation of inflammatory pathways (e.g., cytokine and Retinoic acid-inducible gene I (RIG-I)-like receptor signaling pathways) and immune response like T-cell receptor signaling, antigen processing, and presentation in AAP and the downregulation of metabolic processes like oxidative phosphorylation, pyruvate metabolism.

AB - Biological aging in people with HIV (PWH) with prolonged successful antiretroviral therapy (ART) is convoluted and poorly defined. Here, we aimed to investigate the transcriptomics age estimator (TAE) in a cohort of 178 PWH on prolonged successful ART with immune reconstitution and viral suppression from the Copenhagen Comorbidity (COCOMO) cohort. We also used 143 clinical, demographical, and lifestyle factors to identify the confounders potentially responsible or associated with age acceleration. Among the PWH, 43% had an accelerated aging process (AAP), and 21% had decelerated aging process (DAP). DAP is linked with older age, European ancestry, and higher use of tenofovir disoproxil/alafenamide fumarate. A directionally class-based gene set enrichment analysis identified the upregulation of inflammatory pathways (e.g., cytokine and Retinoic acid-inducible gene I (RIG-I)-like receptor signaling pathways) and immune response like T-cell receptor signaling, antigen processing, and presentation in AAP and the downregulation of metabolic processes like oxidative phosphorylation, pyruvate metabolism.

KW - biological aging

KW - transcriptomics aging clock

KW - treated HIV infection

U2 - 10.1111/acel.13951

DO - 10.1111/acel.13951

M3 - Journal article

C2 - 37548368

AN - SCOPUS:85166931064

VL - 22

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 10

M1 - e13951

ER -

ID: 396107933