Transcatheter aortic valve implantation versus redo surgery for failing surgical aortic bioprostheses: a multicentre propensity score analysis
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Transcatheter aortic valve implantation versus redo surgery for failing surgical aortic bioprostheses : a multicentre propensity score analysis. / Spaziano, Marco; Mylotte, Darren; Thériault-Lauzier, Pascal; De Backer, Ole; Søndergaard, Lars; Bosmans, Johan; Debry, Nicolas; Modine, Thomas; Barbanti, Marco; Tamburino, Corrado; Sinning, Jan-Malte; Grube, Eberhard; Nickenig, Georg; Mellert, Fritz; Bleiziffer, Sabine; Lange, Rüdiger; de Varennes, Benoit; Lachapelle, Kevin; Martucci, Giuseppe; Piazza, Nicolo.
I: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Bind 13, Nr. 10, 20.11.2017, s. 1149-1156.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Transcatheter aortic valve implantation versus redo surgery for failing surgical aortic bioprostheses
T2 - a multicentre propensity score analysis
AU - Spaziano, Marco
AU - Mylotte, Darren
AU - Thériault-Lauzier, Pascal
AU - De Backer, Ole
AU - Søndergaard, Lars
AU - Bosmans, Johan
AU - Debry, Nicolas
AU - Modine, Thomas
AU - Barbanti, Marco
AU - Tamburino, Corrado
AU - Sinning, Jan-Malte
AU - Grube, Eberhard
AU - Nickenig, Georg
AU - Mellert, Fritz
AU - Bleiziffer, Sabine
AU - Lange, Rüdiger
AU - de Varennes, Benoit
AU - Lachapelle, Kevin
AU - Martucci, Giuseppe
AU - Piazza, Nicolo
PY - 2017/11/20
Y1 - 2017/11/20
N2 - AIMS: Transcatheter aortic valve implantation for a failing surgical bioprosthesis (TAV-in-SAV) has become an alternative for patients at high risk for redo surgical aortic valve replacement (redo-SAVR). Comparisons between these approaches are non-existent. This study aimed to compare clinical and echocardiographic outcomes of patients undergoing TAV-in-SAV versus redo-SAVR after accounting for baseline differences by propensity score matching.METHODS AND RESULTS: Patients from seven centres in Europe and Canada who had undergone either TAV-in-SAV (n=79) or redo-SAVR (n=126) were identified. Significant independent predictors used for propensity scoring were age, NYHA functional class, number of prior cardiac surgeries, urgent procedure, pulmonary hypertension, and COPD grade. Using a calliper range of ±0.05, a total of 78 well-matched patient pairs were found. All-cause mortality was similar between groups at 30 days (6.4% redo-SAVR vs. 3.9% TAV-in-SAV; p=0.49) and one year (13.1% redo-SAVR vs. 12.3% TAV-in-SAV; p=0.80). Both groups also showed similar incidences of stroke (0% redo-SAVR vs. 1.3% TAV-in-SAV; p=1.0) and new pacemaker implantation (10.3% redo-SAVR vs. 10.3% TAV-in-SAV; p=1.0). The incidence of acute kidney injury requiring dialysis was numerically lower in the TAV-in-SAV group (11.5% redo-SAVR vs. 3.8% TAV-in-SAV; p=0.13). The TAV-in-SAV group had a significantly shorter median total hospital stay (12 days redo-SAVR vs. 9 days TAV-in-SAV; p=0.001).CONCLUSIONS: Patients with aortic bioprosthesis failure treated with either redo-SAVR or TAV-in-SAV have similar 30-day and one-year clinical outcomes.
AB - AIMS: Transcatheter aortic valve implantation for a failing surgical bioprosthesis (TAV-in-SAV) has become an alternative for patients at high risk for redo surgical aortic valve replacement (redo-SAVR). Comparisons between these approaches are non-existent. This study aimed to compare clinical and echocardiographic outcomes of patients undergoing TAV-in-SAV versus redo-SAVR after accounting for baseline differences by propensity score matching.METHODS AND RESULTS: Patients from seven centres in Europe and Canada who had undergone either TAV-in-SAV (n=79) or redo-SAVR (n=126) were identified. Significant independent predictors used for propensity scoring were age, NYHA functional class, number of prior cardiac surgeries, urgent procedure, pulmonary hypertension, and COPD grade. Using a calliper range of ±0.05, a total of 78 well-matched patient pairs were found. All-cause mortality was similar between groups at 30 days (6.4% redo-SAVR vs. 3.9% TAV-in-SAV; p=0.49) and one year (13.1% redo-SAVR vs. 12.3% TAV-in-SAV; p=0.80). Both groups also showed similar incidences of stroke (0% redo-SAVR vs. 1.3% TAV-in-SAV; p=1.0) and new pacemaker implantation (10.3% redo-SAVR vs. 10.3% TAV-in-SAV; p=1.0). The incidence of acute kidney injury requiring dialysis was numerically lower in the TAV-in-SAV group (11.5% redo-SAVR vs. 3.8% TAV-in-SAV; p=0.13). The TAV-in-SAV group had a significantly shorter median total hospital stay (12 days redo-SAVR vs. 9 days TAV-in-SAV; p=0.001).CONCLUSIONS: Patients with aortic bioprosthesis failure treated with either redo-SAVR or TAV-in-SAV have similar 30-day and one-year clinical outcomes.
U2 - 10.4244/EIJ-D-16-00303
DO - 10.4244/EIJ-D-16-00303
M3 - Journal article
C2 - 28760721
VL - 13
SP - 1149
EP - 1156
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 10
ER -
ID: 195552475