TY - JOUR

T1 - Tooth Loss and Chronic Pain

T2 - A Population-based Analysis of the National Health and Nutrition Examination Survey

AU - Ma, Kevin Sheng Kai

AU - Chan, Shu Yen

AU - Van Dyke, Thomas E.

AU - Wang, Shiow Ing

AU - Wei, James Cheng Chung

AU - Ashina, Sait

N1 - Publisher Copyright: © 2024 United States Association for the Study of Pain, Inc.

PY - 2024

Y1 - 2024

N2 - Poor oral health conditions in adults are associated with chronic pain. A nationwide cross-sectional study was conducted to investigate the link between tooth loss and chronic pain. The study involved 8,662 participants from the National Health and Nutrition Examination Survey. Tooth count was categorized into 4 groups, and chronic pain was defined as persistent pain lasting over 3 months despite treatment. Location of the chronic pain, demographics, comorbidities, lifestyle determinants, and dietary intake were retrieved. Univariate and multivariate logistic regression were used to explore cross-sectional associations between tooth count and chronic pain. Compared to participants with more than 20 teeth, those with severe tooth loss presented greater odds of chronic pain (adjusted odds ratio [aOR] = 2.111, 95% confidence intervals (CI) = 1.213–3.676 for patients with 1–8 teeth). Edentulous participants presented with significantly higher odds of chronic pain in the lower extremities (78.4%) and buttocks (49.5%). In the multivariate model, apart from rheumatic arthritis (aOR = 4.004, 95% CI = 2.766–5.798), variables of higher chronic pain included smoking (aOR = 1.518, 95% CI = 1.228–1.878), and hypertension (aOR = 1.463, 95% CI = 1.013–2.112). On the contrary, being Mexican American (aOR = .603, 95% CI = .414–.880) was associated with lower odds of chronic pain. The findings suggested a significant link between chronic pain and tooth loss, independent of ethnicity, lifestyle determinants, and immune-mediated inflammatory diseases including rheumatoid arthritis. Perspective: A U.S. nationwide study examined tooth loss and chronic pain. Those with severe tooth loss had increased odds of chronic pain. Edentulous individuals presented higher odds of pain in lower extremities and buttocks. This study highlighted the link between tooth loss and chronic pain, independent of comorbidities and lifestyle factors.

AB - Poor oral health conditions in adults are associated with chronic pain. A nationwide cross-sectional study was conducted to investigate the link between tooth loss and chronic pain. The study involved 8,662 participants from the National Health and Nutrition Examination Survey. Tooth count was categorized into 4 groups, and chronic pain was defined as persistent pain lasting over 3 months despite treatment. Location of the chronic pain, demographics, comorbidities, lifestyle determinants, and dietary intake were retrieved. Univariate and multivariate logistic regression were used to explore cross-sectional associations between tooth count and chronic pain. Compared to participants with more than 20 teeth, those with severe tooth loss presented greater odds of chronic pain (adjusted odds ratio [aOR] = 2.111, 95% confidence intervals (CI) = 1.213–3.676 for patients with 1–8 teeth). Edentulous participants presented with significantly higher odds of chronic pain in the lower extremities (78.4%) and buttocks (49.5%). In the multivariate model, apart from rheumatic arthritis (aOR = 4.004, 95% CI = 2.766–5.798), variables of higher chronic pain included smoking (aOR = 1.518, 95% CI = 1.228–1.878), and hypertension (aOR = 1.463, 95% CI = 1.013–2.112). On the contrary, being Mexican American (aOR = .603, 95% CI = .414–.880) was associated with lower odds of chronic pain. The findings suggested a significant link between chronic pain and tooth loss, independent of ethnicity, lifestyle determinants, and immune-mediated inflammatory diseases including rheumatoid arthritis. Perspective: A U.S. nationwide study examined tooth loss and chronic pain. Those with severe tooth loss had increased odds of chronic pain. Edentulous individuals presented higher odds of pain in lower extremities and buttocks. This study highlighted the link between tooth loss and chronic pain, independent of comorbidities and lifestyle factors.

KW - Chronic pain

KW - Inflammation

KW - Nutrition deficiency

KW - Periodontitis

KW - Tooth loss

U2 - 10.1016/j.jpain.2024.104529

DO - 10.1016/j.jpain.2024.104529

M3 - Journal article

C2 - 38588761

AN - SCOPUS:85193602918

JO - The Journal of Pain

JF - The Journal of Pain

SN - 1526-5900

M1 - 104529

ER -