T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise
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T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise. / Dirksen, Carsten; Hansen, Birgitte R; Kolte, Lilian; Haugaard, Steen B; Andersen, Ove.
I: Infectious Diseases, Bind 47, Nr. 12, 2015, s. 919-23.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - T-lymphocyte subset dynamics in well-treated HIV-infected men during a bout of exhausting exercise
AU - Dirksen, Carsten
AU - Hansen, Birgitte R
AU - Kolte, Lilian
AU - Haugaard, Steen B
AU - Andersen, Ove
PY - 2015
Y1 - 2015
N2 - In healthy individuals the substantial lymphocytosis during a bout of exhausting exercise constitutes primarily mature T cells from the peripheral lymphoid organs but naïve T cells are also recruited. This study investigated whether the defective CD4 + T-lymphocyte count in peripheral blood during rest in human immunodeficiency virus (HIV)-infected patients would also be observed following a maximal output ergometer bicycle test. At rest, in 45 well-treated HIV-infected patients, mature and naïve CD4 + T-lymphocyte counts were decreased whereas the less immune active CD8 + T lymphocytes were increased compared with 10 healthy control subjects. In response to exercise mature and naïve CD4 + T lymphocytes increased less and mature and naïve CD8 + T lymphocytes increased most in HIV-infected patients. In conclusion, defective resting mature and naïve CD4 + T lymphocytes in well-treated HIV-infected patients are also reflected in defective acutely mobilized active immune cells following exhausting exercise. The CD4 + T-lymphocyte count is highly sensitive to physical activity.
AB - In healthy individuals the substantial lymphocytosis during a bout of exhausting exercise constitutes primarily mature T cells from the peripheral lymphoid organs but naïve T cells are also recruited. This study investigated whether the defective CD4 + T-lymphocyte count in peripheral blood during rest in human immunodeficiency virus (HIV)-infected patients would also be observed following a maximal output ergometer bicycle test. At rest, in 45 well-treated HIV-infected patients, mature and naïve CD4 + T-lymphocyte counts were decreased whereas the less immune active CD8 + T lymphocytes were increased compared with 10 healthy control subjects. In response to exercise mature and naïve CD4 + T lymphocytes increased less and mature and naïve CD8 + T lymphocytes increased most in HIV-infected patients. In conclusion, defective resting mature and naïve CD4 + T lymphocytes in well-treated HIV-infected patients are also reflected in defective acutely mobilized active immune cells following exhausting exercise. The CD4 + T-lymphocyte count is highly sensitive to physical activity.
U2 - 10.3109/23744235.2015.1069392
DO - 10.3109/23744235.2015.1069392
M3 - Journal article
C2 - 26244875
VL - 47
SP - 919
EP - 923
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 12
ER -
ID: 162900977