Breast cancer is the most common cancer among Danish women. In Denmark, mammography screening has been implemented since 2010. The surgical approach has turned from mastectomy and axillary clearance to breast conserving surgery and sentinel node procedure. The development of radiotherapy is heading towards shorter treatment periods and more precise targeting leading to reduced toxicity. Genomic profiling aims at giving a more personalised adjuvant medical treatment with a high predictive chance of response. Nowadays, more women are offered neoadjuvant treatment, where the systemic treatment is delivered before surgery in order to downsize the disease and reduce surgical treatment.