Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation

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Standard

Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation. / Møller, Dina Leth; Kielsen, Katrine; Nielsen, Claus Henrik; Sengeløv, Henrik; Pedersen, Anders Elm; Ryder, Lars Peter; Müller, Klaus.

I: Immunopharmacology and Immunotoxicology, Bind 44, Nr. 6, 2022, s. 1004-1012.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Møller, DL, Kielsen, K, Nielsen, CH, Sengeløv, H, Pedersen, AE, Ryder, LP & Müller, K 2022, 'Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation', Immunopharmacology and Immunotoxicology, bind 44, nr. 6, s. 1004-1012. https://doi.org/10.1080/08923973.2022.2102989

APA

Møller, D. L., Kielsen, K., Nielsen, C. H., Sengeløv, H., Pedersen, A. E., Ryder, L. P., & Müller, K. (2022). Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation. Immunopharmacology and Immunotoxicology, 44(6), 1004-1012. https://doi.org/10.1080/08923973.2022.2102989

Vancouver

Møller DL, Kielsen K, Nielsen CH, Sengeløv H, Pedersen AE, Ryder LP o.a. Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation. Immunopharmacology and Immunotoxicology. 2022;44(6):1004-1012. https://doi.org/10.1080/08923973.2022.2102989

Author

Møller, Dina Leth ; Kielsen, Katrine ; Nielsen, Claus Henrik ; Sengeløv, Henrik ; Pedersen, Anders Elm ; Ryder, Lars Peter ; Müller, Klaus. / Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation. I: Immunopharmacology and Immunotoxicology. 2022 ; Bind 44, Nr. 6. s. 1004-1012.

Bibtex

@article{67b71f3ff261427faac1cbde8ba3e0b3,

title = "Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation",

abstract = "Background: Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. Methods: We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry. Results: TSLP levels rose after initiation of the conditioning to peak at day +21 after HSCT (p =.03), where TSLP levels correlated with counts of neutrophils (rho = 0.36, p =.04), monocytes (rho = 0.58, p =.006), and lymphocytes (rho = 0.59, p =.02). Overall absolute TSLP levels were not associated with acute or chronic graft-vs-host disease (a/cGvHD). However, patients mounting a sustained increase in TSLP levels at day +90 had a higher risk of cGvHD compared to patients who had returned to pre-conditioning levels at that stage (cumulative incidence: 77% vs. 38%, p =.01). Conclusion: In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.",

keywords = "alloreactivity, chronic GvHD, hematopoietic stem cell transplantation, immune reconstitution, Thymic stromal lymphopoietin",

author = "M{\o}ller, {Dina Leth} and Katrine Kielsen and Nielsen, {Claus Henrik} and Henrik Sengel{\o}v and Pedersen, {Anders Elm} and Ryder, {Lars Peter} and Klaus M{\"u}ller",

note = "Publisher Copyright: {\textcopyright} 2022 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2022",

doi = "10.1080/08923973.2022.2102989",

language = "English",

volume = "44",

pages = "1004--1012",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

publisher = "Taylor & Francis",

number = "6",

}

RIS

TY - JOUR

T1 - Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation

AU - Møller, Dina Leth

AU - Kielsen, Katrine

AU - Nielsen, Claus Henrik

AU - Sengeløv, Henrik

AU - Pedersen, Anders Elm

AU - Ryder, Lars Peter

AU - Müller, Klaus

PY - 2022

Y1 - 2022

N2 - Background: Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. Methods: We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry. Results: TSLP levels rose after initiation of the conditioning to peak at day +21 after HSCT (p =.03), where TSLP levels correlated with counts of neutrophils (rho = 0.36, p =.04), monocytes (rho = 0.58, p =.006), and lymphocytes (rho = 0.59, p =.02). Overall absolute TSLP levels were not associated with acute or chronic graft-vs-host disease (a/cGvHD). However, patients mounting a sustained increase in TSLP levels at day +90 had a higher risk of cGvHD compared to patients who had returned to pre-conditioning levels at that stage (cumulative incidence: 77% vs. 38%, p =.01). Conclusion: In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

AB - Background: Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. Methods: We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry. Results: TSLP levels rose after initiation of the conditioning to peak at day +21 after HSCT (p =.03), where TSLP levels correlated with counts of neutrophils (rho = 0.36, p =.04), monocytes (rho = 0.58, p =.006), and lymphocytes (rho = 0.59, p =.02). Overall absolute TSLP levels were not associated with acute or chronic graft-vs-host disease (a/cGvHD). However, patients mounting a sustained increase in TSLP levels at day +90 had a higher risk of cGvHD compared to patients who had returned to pre-conditioning levels at that stage (cumulative incidence: 77% vs. 38%, p =.01). Conclusion: In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

KW - alloreactivity

KW - chronic GvHD

KW - hematopoietic stem cell transplantation

KW - immune reconstitution

KW - Thymic stromal lymphopoietin

U2 - 10.1080/08923973.2022.2102989

DO - 10.1080/08923973.2022.2102989

M3 - Journal article

C2 - 35899395

AN - SCOPUS:85135156343

VL - 44

SP - 1004

EP - 1012

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

SN - 0892-3973

IS - 6

ER -

ID: 316065097