Thrombolytic and anticoagulation treatment in a rat embolic stroke model

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Thrombolytic and anticoagulation treatment in a rat embolic stroke model. / Rasmussen, Rune Skovgaard; Overgaard, K; Meden, P; Boysen, G.

I: Acta Neurologica Scandinavica, Bind 108, Nr. 3, 09.2003, s. 185-92.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, RS, Overgaard, K, Meden, P & Boysen, G 2003, 'Thrombolytic and anticoagulation treatment in a rat embolic stroke model', Acta Neurologica Scandinavica, bind 108, nr. 3, s. 185-92.

APA

Rasmussen, R. S., Overgaard, K., Meden, P., & Boysen, G. (2003). Thrombolytic and anticoagulation treatment in a rat embolic stroke model. Acta Neurologica Scandinavica, 108(3), 185-92.

Vancouver

Rasmussen RS, Overgaard K, Meden P, Boysen G. Thrombolytic and anticoagulation treatment in a rat embolic stroke model. Acta Neurologica Scandinavica. 2003 sep.;108(3):185-92.

Author

Rasmussen, Rune Skovgaard ; Overgaard, K ; Meden, P ; Boysen, G. / Thrombolytic and anticoagulation treatment in a rat embolic stroke model. I: Acta Neurologica Scandinavica. 2003 ; Bind 108, Nr. 3. s. 185-92.

Bibtex

@article{b7cd4b71de6e499baeb1adfbbeac715a,
title = "Thrombolytic and anticoagulation treatment in a rat embolic stroke model",
abstract = "OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.",
keywords = "Angiography, Animals, Anticoagulants, Disease Models, Animal, Drug Therapy, Combination, Fibrinolytic Agents, Intracranial Embolism, Male, Oligosaccharides, Plasminogen Activators, Rats, Rats, Sprague-Dawley, Stroke, Thrombolytic Therapy",
author = "Rasmussen, {Rune Skovgaard} and K Overgaard and P Meden and G Boysen",
year = "2003",
month = sep,
language = "English",
volume = "108",
pages = "185--92",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Thrombolytic and anticoagulation treatment in a rat embolic stroke model

AU - Rasmussen, Rune Skovgaard

AU - Overgaard, K

AU - Meden, P

AU - Boysen, G

PY - 2003/9

Y1 - 2003/9

N2 - OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.

AB - OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.

KW - Angiography

KW - Animals

KW - Anticoagulants

KW - Disease Models, Animal

KW - Drug Therapy, Combination

KW - Fibrinolytic Agents

KW - Intracranial Embolism

KW - Male

KW - Oligosaccharides

KW - Plasminogen Activators

KW - Rats

KW - Rats, Sprague-Dawley

KW - Stroke

KW - Thrombolytic Therapy

M3 - Journal article

C2 - 12911462

VL - 108

SP - 185

EP - 192

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 3

ER -

ID: 117687259