Three-year follow-up of sentinel node-negative patients with early oral cavity squamous cell carcinoma
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Three-year follow-up of sentinel node-negative patients with early oral cavity squamous cell carcinoma. / Sebbesen, Lars; Bilde, Anders; Therkildsen, Marianne; Mortensen, Jann; Specht, Lena; von Buchwald, Christian.
I: Head & Neck (Print Edition), Bind 36, Nr. 8, 08.2014, s. 1109-1112.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Three-year follow-up of sentinel node-negative patients with early oral cavity squamous cell carcinoma
AU - Sebbesen, Lars
AU - Bilde, Anders
AU - Therkildsen, Marianne
AU - Mortensen, Jann
AU - Specht, Lena
AU - von Buchwald, Christian
N1 - Copyright © 2013 Wiley Periodicals, Inc.
PY - 2014/8
Y1 - 2014/8
N2 - BACKGROUND: Resection of the primary tumor followed by sentinel node biopsy (SNB) for the clinically N0 patient has been implemented in our Head and Neck University Center. The purpose of this study was to report on the outcome for patients with negative SNB.METHODS: From April 2007 to October 2009, 53 consecutive SNB-negative patients with oral cavity squamous cell carcinoma (SCC) T1 to T2 were accrued. Follow-up was done continuously with the most recent examination in October 2011. The location of the sentinel lymph nodes was determined using dynamic and planar lymphoscintigraphy and single photon emission CT (SPECT)-CT. Intraoperatively, a hand-held gamma probe was applied. The harvested sentinel lymph nodes underwent histopathologic examination using step-serial sectioning at 150-μm intervals and immunohistochemistry. In the follow-up period, we observed and examined the SNB-negative patients for recurrence, morbidity, and mortality.RESULTS: Fifty-three SNB-negative patients were identified. Eight patients received adjuvant radiotherapy (RT) because of incomplete excision on the T site after the primary operation. An additional 2 patients received RT because of recurrences on the T site and N site. One patient died of recurrence on the T site and N site without having received additional treatment. Six patients died of nonrelated causes. During follow-up, 3 patients with both T-site and N-site recurrence were found. No case of isolated recurrence on the N site only was found. Thirty-six SNB-negative patients treated only surgically with a median follow-up of 37 months (range, 25-52 months) and no recurrence remain under active review.CONCLUSION: Only 3 of the SNB-negative patients subsequently developed recurrence in the T site and N site. The remaining 36 patients had no N-site recurrence at median follow-up of 37 months.
AB - BACKGROUND: Resection of the primary tumor followed by sentinel node biopsy (SNB) for the clinically N0 patient has been implemented in our Head and Neck University Center. The purpose of this study was to report on the outcome for patients with negative SNB.METHODS: From April 2007 to October 2009, 53 consecutive SNB-negative patients with oral cavity squamous cell carcinoma (SCC) T1 to T2 were accrued. Follow-up was done continuously with the most recent examination in October 2011. The location of the sentinel lymph nodes was determined using dynamic and planar lymphoscintigraphy and single photon emission CT (SPECT)-CT. Intraoperatively, a hand-held gamma probe was applied. The harvested sentinel lymph nodes underwent histopathologic examination using step-serial sectioning at 150-μm intervals and immunohistochemistry. In the follow-up period, we observed and examined the SNB-negative patients for recurrence, morbidity, and mortality.RESULTS: Fifty-three SNB-negative patients were identified. Eight patients received adjuvant radiotherapy (RT) because of incomplete excision on the T site after the primary operation. An additional 2 patients received RT because of recurrences on the T site and N site. One patient died of recurrence on the T site and N site without having received additional treatment. Six patients died of nonrelated causes. During follow-up, 3 patients with both T-site and N-site recurrence were found. No case of isolated recurrence on the N site only was found. Thirty-six SNB-negative patients treated only surgically with a median follow-up of 37 months (range, 25-52 months) and no recurrence remain under active review.CONCLUSION: Only 3 of the SNB-negative patients subsequently developed recurrence in the T site and N site. The remaining 36 patients had no N-site recurrence at median follow-up of 37 months.
KW - Adult
KW - Aged
KW - Carcinoma, Squamous Cell
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Immunohistochemistry
KW - Lymph Nodes
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Neoplasm Recurrence, Local
KW - Prognosis
KW - Prospective Studies
KW - Radiotherapy, Adjuvant
KW - Sentinel Lymph Node Biopsy
U2 - 10.1002/hed.23414
DO - 10.1002/hed.23414
M3 - Journal article
C2 - 23804530
VL - 36
SP - 1109
EP - 1112
JO - Head & Neck (Print Edition)
JF - Head & Neck (Print Edition)
SN - 1043-3074
IS - 8
ER -
ID: 138496878