Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia

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Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia. / van Schijndel, Jessica E; van Loo, Karen M J; van Zweeden, Martine; Djurovic, Srdjan; Andreassen, Ole A; Hansen, Thomas; Werge, Thomas; Kallunki, Pekka; Pedersen, Jan T; Martens, Gerard J M.

I: Journal of Psychiatric Research, Bind 43, Nr. 15, 2009, s. 1195-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

van Schijndel, JE, van Loo, KMJ, van Zweeden, M, Djurovic, S, Andreassen, OA, Hansen, T, Werge, T, Kallunki, P, Pedersen, JT & Martens, GJM 2009, 'Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia', Journal of Psychiatric Research, bind 43, nr. 15, s. 1195-9. https://doi.org/10.1016/j.jpsychires.2009.04.006, https://doi.org/10.1016/j.jpsychires.2009.04.006

APA

van Schijndel, J. E., van Loo, K. M. J., van Zweeden, M., Djurovic, S., Andreassen, O. A., Hansen, T., Werge, T., Kallunki, P., Pedersen, J. T., & Martens, G. J. M. (2009). Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia. Journal of Psychiatric Research, 43(15), 1195-9. https://doi.org/10.1016/j.jpsychires.2009.04.006, https://doi.org/10.1016/j.jpsychires.2009.04.006

Vancouver

van Schijndel JE, van Loo KMJ, van Zweeden M, Djurovic S, Andreassen OA, Hansen T o.a. Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia. Journal of Psychiatric Research. 2009;43(15):1195-9. https://doi.org/10.1016/j.jpsychires.2009.04.006, https://doi.org/10.1016/j.jpsychires.2009.04.006

Author

van Schijndel, Jessica E ; van Loo, Karen M J ; van Zweeden, Martine ; Djurovic, Srdjan ; Andreassen, Ole A ; Hansen, Thomas ; Werge, Thomas ; Kallunki, Pekka ; Pedersen, Jan T ; Martens, Gerard J M. / Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia. I: Journal of Psychiatric Research. 2009 ; Bind 43, Nr. 15. s. 1195-9.

Bibtex

@article{ac901380a5f811df928f000ea68e967b,

title = "Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia",

abstract = "Schizophrenia is a complex neurodevelopmental disorder that is thought to be induced by an interaction between predisposing genes and environmental stressors. To identify predisposing genetic factors, we performed a targeted (mostly neurodevelopmental) gene approach involving the screening of 396 selected non-synonymous single-nucleotide polymorphisms (SNPs) in three independent Caucasian schizophrenia case-control cohorts (USA, Denmark and Norway). A meta-analysis revealed ten non-synonymous SNPs that were nominally associated with schizophrenia, nine of which have not been previously linked to the disorder. Risk alleles are in TRKA (rs6336), BARD1 (rs28997576), LAMA5 (rs3810548), DKK2 (rs7037102), NOD2 (rs2066844) and RELN (rs2229860), whereas protective alleles are in NOD2 (rs2066845), NRG1 (rs10503929), ADAM7 (rs13259668) and TNR (rs859427). Following correction for multiple testing, the most attractive candidate for further study concerns SNP rs6336 (q=0.12) that causes the substitution of an evolutionarily highly conserved amino acid residue in the kinase domain of the neurodevelopmentally important receptor TRKA. Thus, TRKA signaling may represent a novel susceptibility pathway for schizophrenia.",

author = "{van Schijndel}, {Jessica E} and {van Loo}, {Karen M J} and {van Zweeden}, Martine and Srdjan Djurovic and Andreassen, {Ole A} and Thomas Hansen and Thomas Werge and Pekka Kallunki and Pedersen, {Jan T} and Martens, {Gerard J M}",

note = "Keywords: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chi-Square Distribution; Cohort Studies; Denmark; European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptor, trkA; Schizophrenia; United States",

year = "2009",

doi = "10.1016/j.jpsychires.2009.04.006",

language = "English",

volume = "43",

pages = "1195--9",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Pergamon Press",

number = "15",

}

RIS

TY - JOUR

T1 - Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia

AU - van Schijndel, Jessica E

AU - van Loo, Karen M J

AU - van Zweeden, Martine

AU - Djurovic, Srdjan

AU - Andreassen, Ole A

AU - Hansen, Thomas

AU - Werge, Thomas

AU - Kallunki, Pekka

AU - Pedersen, Jan T

AU - Martens, Gerard J M

N1 - Keywords: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chi-Square Distribution; Cohort Studies; Denmark; European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptor, trkA; Schizophrenia; United States

PY - 2009

Y1 - 2009

N2 - Schizophrenia is a complex neurodevelopmental disorder that is thought to be induced by an interaction between predisposing genes and environmental stressors. To identify predisposing genetic factors, we performed a targeted (mostly neurodevelopmental) gene approach involving the screening of 396 selected non-synonymous single-nucleotide polymorphisms (SNPs) in three independent Caucasian schizophrenia case-control cohorts (USA, Denmark and Norway). A meta-analysis revealed ten non-synonymous SNPs that were nominally associated with schizophrenia, nine of which have not been previously linked to the disorder. Risk alleles are in TRKA (rs6336), BARD1 (rs28997576), LAMA5 (rs3810548), DKK2 (rs7037102), NOD2 (rs2066844) and RELN (rs2229860), whereas protective alleles are in NOD2 (rs2066845), NRG1 (rs10503929), ADAM7 (rs13259668) and TNR (rs859427). Following correction for multiple testing, the most attractive candidate for further study concerns SNP rs6336 (q=0.12) that causes the substitution of an evolutionarily highly conserved amino acid residue in the kinase domain of the neurodevelopmentally important receptor TRKA. Thus, TRKA signaling may represent a novel susceptibility pathway for schizophrenia.

AB - Schizophrenia is a complex neurodevelopmental disorder that is thought to be induced by an interaction between predisposing genes and environmental stressors. To identify predisposing genetic factors, we performed a targeted (mostly neurodevelopmental) gene approach involving the screening of 396 selected non-synonymous single-nucleotide polymorphisms (SNPs) in three independent Caucasian schizophrenia case-control cohorts (USA, Denmark and Norway). A meta-analysis revealed ten non-synonymous SNPs that were nominally associated with schizophrenia, nine of which have not been previously linked to the disorder. Risk alleles are in TRKA (rs6336), BARD1 (rs28997576), LAMA5 (rs3810548), DKK2 (rs7037102), NOD2 (rs2066844) and RELN (rs2229860), whereas protective alleles are in NOD2 (rs2066845), NRG1 (rs10503929), ADAM7 (rs13259668) and TNR (rs859427). Following correction for multiple testing, the most attractive candidate for further study concerns SNP rs6336 (q=0.12) that causes the substitution of an evolutionarily highly conserved amino acid residue in the kinase domain of the neurodevelopmentally important receptor TRKA. Thus, TRKA signaling may represent a novel susceptibility pathway for schizophrenia.

U2 - 10.1016/j.jpsychires.2009.04.006

DO - 10.1016/j.jpsychires.2009.04.006

M3 - Journal article

C2 - 19435634

VL - 43

SP - 1195

EP - 1199

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 15

ER -

ID: 21336680