The vascular circadian clock in chronic kidney disease

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The vascular circadian clock in chronic kidney disease. / Egstrand, Søren; Mace, Maria L.; Olgaard, Klaus; Lewin, Ewa.

I: Cells, Bind 10, Nr. 7, 1769, 2021.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Egstrand, S, Mace, ML, Olgaard, K & Lewin, E 2021, 'The vascular circadian clock in chronic kidney disease', Cells, bind 10, nr. 7, 1769. https://doi.org/10.3390/cells10071769

APA

Egstrand, S., Mace, M. L., Olgaard, K., & Lewin, E. (2021). The vascular circadian clock in chronic kidney disease. Cells, 10(7), [1769]. https://doi.org/10.3390/cells10071769

Vancouver

Egstrand S, Mace ML, Olgaard K, Lewin E. The vascular circadian clock in chronic kidney disease. Cells. 2021;10(7). 1769. https://doi.org/10.3390/cells10071769

Author

Egstrand, Søren ; Mace, Maria L. ; Olgaard, Klaus ; Lewin, Ewa. / The vascular circadian clock in chronic kidney disease. I: Cells. 2021 ; Bind 10, Nr. 7.

Bibtex

@article{7c87c76417b149aaaa8f917c9233f4dd,

title = "The vascular circadian clock in chronic kidney disease",

abstract = "Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.",

keywords = "Adhesion molecules, Cardiovascular disease, Ccl2, ICAM-1, Inflammation, Thrombomodulin, Uremia, Vascular calcification, VCAM-1",

author = "S{\o}ren Egstrand and Mace, {Maria L.} and Klaus Olgaard and Ewa Lewin",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/cells10071769",

language = "English",

volume = "10",

journal = "Cells",

issn = "2073-4409",

publisher = "MDPI AG",

number = "7",

}

RIS

TY - JOUR

T1 - The vascular circadian clock in chronic kidney disease

AU - Egstrand, Søren

AU - Mace, Maria L.

AU - Olgaard, Klaus

AU - Lewin, Ewa

PY - 2021

Y1 - 2021

N2 - Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.

AB - Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.

KW - Adhesion molecules

KW - Cardiovascular disease

KW - Ccl2

KW - ICAM-1

KW - Inflammation

KW - Thrombomodulin

KW - Uremia

KW - Vascular calcification

KW - VCAM-1

U2 - 10.3390/cells10071769

DO - 10.3390/cells10071769

M3 - Review

C2 - 34359937

AN - SCOPUS:85114076963

VL - 10

JO - Cells

JF - Cells

SN - 2073-4409

IS - 7

M1 - 1769

ER -

ID: 303675423