The use of a systems approach to increase NAD+ in human participants
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Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement – Nuchido TIME+® (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.
Originalsprog | Engelsk |
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Artikelnummer | 7 |
Tidsskrift | npj Aging |
Vol/bind | 10 |
Antal sider | 12 |
ISSN | 2731-6068 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
The authors thank Dr Willian Cheung, Northumbria University, for carrying out analysis of samples by LC–MS. The study was co-funded by Northumbria University (studentships to J.D.H. and S.N.Z.Q. and infrastructure support) and Nuchido Ltd. (contribution to studentship for S.N.Z.Q., consumables costs, staff costs of S.S.C.).
Publisher Copyright:
© 2024, The Author(s).
ID: 383005966