The SWEET Project 10-Year Benchmarking in 19 Countries Worldwide Is Associated with Improved HbA1c and Increased Use of Diabetes Technology in Youth with Type 1 Diabetes

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  • Peter Gerhardsson
  • Anke Schwandt
  • Michael Witsch
  • Olga Kordonouri
  • Svensson, Jannet
  • Gun Forsander
  • Tadej Battelino
  • Henk Veeze
  • Thomas Danne

Objective: The international SWEET registry (NCT04427189) was initiated in 2008 to improve outcomes in pediatric diabetes. A 10-year follow-up allowed studying time trends of key quality indicators in 22 centers from Europe, Australia, Canada, and India in youth with type 1 diabetes (T1D). Methods: Aggregated data per person with T1D <25 years of age were compared between 2008-2010 and 2016-2018. Hierarchic linear and logistic regression models were applied. Models were adjusted for gender, age-, and diabetes duration groups. Results: The first and second time periods included 4930 versus 13,654 persons, 51% versus 52% male, median age 11.3 [Q1; Q3: 7.9; 14.5] versus 13.3 [9.7; 16.4] years, and T1D duration 2.9 [0.8; 6.4] versus 4.2 [1.4; 7.7] years. The adjusted hemoglobin A1C (HbA1c) improved from 68 (95% confidence interval [CI]: 66-70) to 63 (60; 65) mmol/mol (P < 0.0001) or 8.4 (95% CI: 8.2-8.6) to 7.9 (7.6; 8.1) % (P < 0.0001). Across all age groups, HbA1c was significantly lower in pump and sensor users. Severe hypoglycemia declined from 3.8% (2.9; 5.0) to 2.4% (1.9; 3.1) (P < 0.0001), whereas diabetic ketoacidosis events increased significantly with injection therapy only. Body mass index-standard deviation score also showed significant improvements 0.55 (0.46; 0.64) versus 0.42 (0.33; 0.51) (P < 0.0001). Over time, the increase in pump use from 34% to 44% preceded the increase in HbA1c target achievement (<53 mmol/mol) from 21% to 34%. Conclusions: Twice yearly benchmarking within the SWEET registry was associated with significantly improved HbA1c on a background of increasing pump and sensor use for 10 years in young persons with T1D. Trial Registration: NCT04427189.

OriginalsprogEngelsk
TidsskriftDiabetes Technology and Therapeutics
Vol/bind23
Udgave nummer7
Sider (fra-til)491-499
Antal sider9
ISSN1520-9156
DOI
StatusUdgivet - 2021

Bibliografisk note

Funding Information:
SWEET is a registered nonprofit charity in Hannover, Germany. It is financed through membership fees of the participating centers (based on income of country of residence according to the World Bank) and corporate members. We acknowledge with gratitude the support from the following SWEET e.V. corporate members—in alphabetical order: Abbott, Boehringer Ingelheim, DexCom Inc., Insulet, Eli Lilly & Co., Medtronic Europe, Sanofi.

Publisher Copyright:
© Peter Gerhardsson, et al., 2021; Published by Mary Ann Liebert, Inc. 2021.

ID: 304482581