The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The search for neuroimaging and cognitive endophenotypes : A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder. / Miskowiak, Kamilla W.; Kjærstad, Hanne L; Meluken, Iselin; Petersen, Jeff Zarp; Maciel, Beatriz R.; Köhler, Cristiano A; Vinberg, Maj; Kessing, Lars V.; Carvalho, André F.

I: Neuroscience and Biobehavioral Reviews, Bind 73, 02.2017, s. 1-22.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Miskowiak, KW, Kjærstad, HL, Meluken, I, Petersen, JZ, Maciel, BR, Köhler, CA, Vinberg, M, Kessing, LV & Carvalho, AF 2017, 'The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder', Neuroscience and Biobehavioral Reviews, bind 73, s. 1-22. https://doi.org/10.1016/j.neubiorev.2016.12.011

APA

Miskowiak, K. W., Kjærstad, H. L., Meluken, I., Petersen, J. Z., Maciel, B. R., Köhler, C. A., Vinberg, M., Kessing, L. V., & Carvalho, A. F. (2017). The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder. Neuroscience and Biobehavioral Reviews, 73, 1-22. https://doi.org/10.1016/j.neubiorev.2016.12.011

Vancouver

Miskowiak KW, Kjærstad HL, Meluken I, Petersen JZ, Maciel BR, Köhler CA o.a. The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder. Neuroscience and Biobehavioral Reviews. 2017 feb.;73:1-22. https://doi.org/10.1016/j.neubiorev.2016.12.011

Author

Miskowiak, Kamilla W. ; Kjærstad, Hanne L ; Meluken, Iselin ; Petersen, Jeff Zarp ; Maciel, Beatriz R. ; Köhler, Cristiano A ; Vinberg, Maj ; Kessing, Lars V. ; Carvalho, André F. / The search for neuroimaging and cognitive endophenotypes : A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder. I: Neuroscience and Biobehavioral Reviews. 2017 ; Bind 73. s. 1-22.

Bibtex

@article{9ca06380df704de1992aac83bc19f2fd,
title = "The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder",
abstract = "The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: {\textquoteleft}cold{\textquoteright} and {\textquoteleft}hot{\textquoteright} cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.",
keywords = "Bipolar disorder, Cognition, Endophenotype, Mood disorder, Neurocognition, Neuroimaging, Pathophysiology, Psychiatry",
author = "Miskowiak, {Kamilla W.} and Kj{\ae}rstad, {Hanne L} and Iselin Meluken and Petersen, {Jeff Zarp} and Maciel, {Beatriz R.} and K{\"o}hler, {Cristiano A} and Maj Vinberg and Kessing, {Lars V.} and Carvalho, {Andr{\'e} F}",
year = "2017",
month = feb,
doi = "10.1016/j.neubiorev.2016.12.011",
language = "English",
volume = "73",
pages = "1--22",
journal = "Neuroscience & Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - The search for neuroimaging and cognitive endophenotypes

T2 - A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder

AU - Miskowiak, Kamilla W.

AU - Kjærstad, Hanne L

AU - Meluken, Iselin

AU - Petersen, Jeff Zarp

AU - Maciel, Beatriz R.

AU - Köhler, Cristiano A

AU - Vinberg, Maj

AU - Kessing, Lars V.

AU - Carvalho, André F

PY - 2017/2

Y1 - 2017/2

N2 - The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: ‘cold’ and ‘hot’ cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.

AB - The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: ‘cold’ and ‘hot’ cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.

KW - Bipolar disorder

KW - Cognition

KW - Endophenotype

KW - Mood disorder

KW - Neurocognition

KW - Neuroimaging

KW - Pathophysiology

KW - Psychiatry

U2 - 10.1016/j.neubiorev.2016.12.011

DO - 10.1016/j.neubiorev.2016.12.011

M3 - Review

C2 - 27979650

AN - SCOPUS:85006957493

VL - 73

SP - 1

EP - 22

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

SN - 0149-7634

ER -

ID: 180934564