The Scottish Structural Proteomics Facility: targets, methods and outputs

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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The Scottish Structural Proteomics Facility: targets, methods and outputs. / Oke, Muse; Carter, Lester G; Johnson, Kenneth A; Liu, Huanting; McMahon, Stephen A; Yan, Xuan; Kerou, Melina; Weikart, Nadine D; Kadi, Nadia; Sheikh, Md Arif; Schmelz, Stefan; Dorward, Mark; Zawadzki, Michal; Cozens, Christopher; Falconer, Helen; Powers, Helen; Overton, Ian M; van Niekerk, C A Johannes; Peng, Xu; Patel, Prakash; Garrett, Roger Antony; Prangishvili, David; Botting, Catherine H; Coote, Peter J; Dryden, David T F; Barton, Geoffrey J; Schwarz-Linek, Ulrich; Challis, Gregory L; Taylor, Garry L; White, Malcolm F; Naismith, James H.

I: Journal of Structural and Functional Genomics, Bind 11, Nr. 2, 01.06.2010, s. 167-80.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Oke, M, Carter, LG, Johnson, KA, Liu, H, McMahon, SA, Yan, X, Kerou, M, Weikart, ND, Kadi, N, Sheikh, MA, Schmelz, S, Dorward, M, Zawadzki, M, Cozens, C, Falconer, H, Powers, H, Overton, IM, van Niekerk, CAJ, Peng, X, Patel, P, Garrett, RA, Prangishvili, D, Botting, CH, Coote, PJ, Dryden, DTF, Barton, GJ, Schwarz-Linek, U, Challis, GL, Taylor, GL, White, MF & Naismith, JH 2010, 'The Scottish Structural Proteomics Facility: targets, methods and outputs', Journal of Structural and Functional Genomics, bind 11, nr. 2, s. 167-80. https://doi.org/10.1007/s10969-010-9090-y

APA

Oke, M., Carter, L. G., Johnson, K. A., Liu, H., McMahon, S. A., Yan, X., Kerou, M., Weikart, N. D., Kadi, N., Sheikh, M. A., Schmelz, S., Dorward, M., Zawadzki, M., Cozens, C., Falconer, H., Powers, H., Overton, I. M., van Niekerk, C. A. J., Peng, X., ... Naismith, J. H. (2010). The Scottish Structural Proteomics Facility: targets, methods and outputs. Journal of Structural and Functional Genomics, 11(2), 167-80. https://doi.org/10.1007/s10969-010-9090-y

Vancouver

Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X o.a. The Scottish Structural Proteomics Facility: targets, methods and outputs. Journal of Structural and Functional Genomics. 2010 jun. 1;11(2):167-80. https://doi.org/10.1007/s10969-010-9090-y

Author

Oke, Muse ; Carter, Lester G ; Johnson, Kenneth A ; Liu, Huanting ; McMahon, Stephen A ; Yan, Xuan ; Kerou, Melina ; Weikart, Nadine D ; Kadi, Nadia ; Sheikh, Md Arif ; Schmelz, Stefan ; Dorward, Mark ; Zawadzki, Michal ; Cozens, Christopher ; Falconer, Helen ; Powers, Helen ; Overton, Ian M ; van Niekerk, C A Johannes ; Peng, Xu ; Patel, Prakash ; Garrett, Roger Antony ; Prangishvili, David ; Botting, Catherine H ; Coote, Peter J ; Dryden, David T F ; Barton, Geoffrey J ; Schwarz-Linek, Ulrich ; Challis, Gregory L ; Taylor, Garry L ; White, Malcolm F ; Naismith, James H. / The Scottish Structural Proteomics Facility: targets, methods and outputs. I: Journal of Structural and Functional Genomics. 2010 ; Bind 11, Nr. 2. s. 167-80.

Bibtex

@article{1895adbb989442cc8132dff217a4100d,
title = "The Scottish Structural Proteomics Facility: targets, methods and outputs",
abstract = "The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.",
keywords = "Computational Biology, Crystallization, Humans, Laboratories, Proteins, Proteomics, Scotland",
author = "Muse Oke and Carter, {Lester G} and Johnson, {Kenneth A} and Huanting Liu and McMahon, {Stephen A} and Xuan Yan and Melina Kerou and Weikart, {Nadine D} and Nadia Kadi and Sheikh, {Md Arif} and Stefan Schmelz and Mark Dorward and Michal Zawadzki and Christopher Cozens and Helen Falconer and Helen Powers and Overton, {Ian M} and {van Niekerk}, {C A Johannes} and Xu Peng and Prakash Patel and Garrett, {Roger Antony} and David Prangishvili and Botting, {Catherine H} and Coote, {Peter J} and Dryden, {David T F} and Barton, {Geoffrey J} and Ulrich Schwarz-Linek and Challis, {Gregory L} and Taylor, {Garry L} and White, {Malcolm F} and Naismith, {James H}",
year = "2010",
month = jun,
day = "1",
doi = "10.1007/s10969-010-9090-y",
language = "English",
volume = "11",
pages = "167--80",
journal = "Journal of Structural and Functional Genomics",
issn = "1345-711X",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - The Scottish Structural Proteomics Facility: targets, methods and outputs

AU - Oke, Muse

AU - Carter, Lester G

AU - Johnson, Kenneth A

AU - Liu, Huanting

AU - McMahon, Stephen A

AU - Yan, Xuan

AU - Kerou, Melina

AU - Weikart, Nadine D

AU - Kadi, Nadia

AU - Sheikh, Md Arif

AU - Schmelz, Stefan

AU - Dorward, Mark

AU - Zawadzki, Michal

AU - Cozens, Christopher

AU - Falconer, Helen

AU - Powers, Helen

AU - Overton, Ian M

AU - van Niekerk, C A Johannes

AU - Peng, Xu

AU - Patel, Prakash

AU - Garrett, Roger Antony

AU - Prangishvili, David

AU - Botting, Catherine H

AU - Coote, Peter J

AU - Dryden, David T F

AU - Barton, Geoffrey J

AU - Schwarz-Linek, Ulrich

AU - Challis, Gregory L

AU - Taylor, Garry L

AU - White, Malcolm F

AU - Naismith, James H

PY - 2010/6/1

Y1 - 2010/6/1

N2 - The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.

AB - The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.

KW - Computational Biology

KW - Crystallization

KW - Humans

KW - Laboratories

KW - Proteins

KW - Proteomics

KW - Scotland

U2 - 10.1007/s10969-010-9090-y

DO - 10.1007/s10969-010-9090-y

M3 - Journal article

C2 - 20419351

VL - 11

SP - 167

EP - 180

JO - Journal of Structural and Functional Genomics

JF - Journal of Structural and Functional Genomics

SN - 1345-711X

IS - 2

ER -

ID: 33493801