The role of intrinsic disorder in binding of plant microtubule-associated proteins to the cytoskeleton
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The role of intrinsic disorder in binding of plant microtubule-associated proteins to the cytoskeleton. / Gonzalez, Jordy Perez; Frandsen, Kristian E H; Kesten, Christopher.
I: Cytoskeleton, Bind 80, Nr. 11-12, 2023, s. 404-436.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The role of intrinsic disorder in binding of plant microtubule-associated proteins to the cytoskeleton
AU - Gonzalez, Jordy Perez
AU - Frandsen, Kristian E H
AU - Kesten, Christopher
N1 - © 2023 The Authors. Cytoskeleton published by Wiley Periodicals LLC.
PY - 2023
Y1 - 2023
N2 - Microtubules (MTs) represent one of the main components of the eukaryotic cytoskeleton and support numerous critical cellular functions. MTs are in principle tube-like structures that can grow and shrink in a highly dynamic manner; a process largely controlled by microtubule-associated proteins (MAPs). Plant MAPs are a phylogenetically diverse group of proteins that nonetheless share many common biophysical characteristics and often contain large stretches of intrinsic protein disorder. These intrinsically disordered regions are determinants of many MAP-MT interactions, in which structural flexibility enables low-affinity protein-protein interactions that enable a fine-tuned regulation of MT cytoskeleton dynamics. Notably, intrinsic disorder is one of the major obstacles in functional and structural studies of MAPs and represents the principal present-day challenge to decipher how MAPs interact with MTs. Here, we review plant MAPs from an intrinsic protein disorder perspective, by providing a complete and up-to-date summary of all currently known members, and address the current and future challenges in functional and structural characterization of MAPs.
AB - Microtubules (MTs) represent one of the main components of the eukaryotic cytoskeleton and support numerous critical cellular functions. MTs are in principle tube-like structures that can grow and shrink in a highly dynamic manner; a process largely controlled by microtubule-associated proteins (MAPs). Plant MAPs are a phylogenetically diverse group of proteins that nonetheless share many common biophysical characteristics and often contain large stretches of intrinsic protein disorder. These intrinsically disordered regions are determinants of many MAP-MT interactions, in which structural flexibility enables low-affinity protein-protein interactions that enable a fine-tuned regulation of MT cytoskeleton dynamics. Notably, intrinsic disorder is one of the major obstacles in functional and structural studies of MAPs and represents the principal present-day challenge to decipher how MAPs interact with MTs. Here, we review plant MAPs from an intrinsic protein disorder perspective, by providing a complete and up-to-date summary of all currently known members, and address the current and future challenges in functional and structural characterization of MAPs.
U2 - 10.1002/cm.21773
DO - 10.1002/cm.21773
M3 - Review
C2 - 37578201
VL - 80
SP - 404
EP - 436
JO - Cytoskeleton
JF - Cytoskeleton
SN - 1949-3592
IS - 11-12
ER -
ID: 363061147