The Role of Endothelin in the Pathophysiology of Migraine: a Systematic Review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
The Role of Endothelin in the Pathophysiology of Migraine : a Systematic Review. / Iljazi, Afrim; Ayata, Cenk; Ashina, Messoud; Hougaard, Anders.
I: Current Pain and Headache Reports, Bind 22, 27, 2018.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The Role of Endothelin in the Pathophysiology of Migraine
T2 - a Systematic Review
AU - Iljazi, Afrim
AU - Ayata, Cenk
AU - Ashina, Messoud
AU - Hougaard, Anders
PY - 2018
Y1 - 2018
N2 - Purpose of Review: Vasoactive peptides play a key role in the attack-initiating cascade of migraine. Recent studies have highlighted a potentially important role for endothelin-1, a potent vasoconstrictor peptide, in migraine pathophysiology. Here, we review the current data on endothelin’s involvement in migraine. Recent Findings: We identified 23 articles. Nine studies reported on endothelin-1 plasma concentrations in patients with migraine, eight studies investigated relevant genetic associations, five studies investigated endothelin-1 and spreading depression in animals, and one randomized controlled clinical trial tested the efficacy of an endothelin antagonist in the acute treatment of migraine in patients both with and without aura. Elevated endothelin-1 plasma levels have been reported in the early phase of migraine attacks. Genetic abnormalities related to the endothelin type A receptor have been reported in migraineurs. Endothelin-1 potently induces spreading depression in animals, which may explain the connection between endothelial irritation and migraine aura. Summary: Endothelin-1 could be a primary factor in the attack-triggering cascade of migraine attacks with and without aura. Additional studies in humans and animal models are needed to further elucidate the role of endothelin-1 in migraine.
AB - Purpose of Review: Vasoactive peptides play a key role in the attack-initiating cascade of migraine. Recent studies have highlighted a potentially important role for endothelin-1, a potent vasoconstrictor peptide, in migraine pathophysiology. Here, we review the current data on endothelin’s involvement in migraine. Recent Findings: We identified 23 articles. Nine studies reported on endothelin-1 plasma concentrations in patients with migraine, eight studies investigated relevant genetic associations, five studies investigated endothelin-1 and spreading depression in animals, and one randomized controlled clinical trial tested the efficacy of an endothelin antagonist in the acute treatment of migraine in patients both with and without aura. Elevated endothelin-1 plasma levels have been reported in the early phase of migraine attacks. Genetic abnormalities related to the endothelin type A receptor have been reported in migraineurs. Endothelin-1 potently induces spreading depression in animals, which may explain the connection between endothelial irritation and migraine aura. Summary: Endothelin-1 could be a primary factor in the attack-triggering cascade of migraine attacks with and without aura. Additional studies in humans and animal models are needed to further elucidate the role of endothelin-1 in migraine.
KW - Aura
KW - Endothelium
KW - Spreading depression
KW - Vascular
U2 - 10.1007/s11916-018-0682-8
DO - 10.1007/s11916-018-0682-8
M3 - Review
C2 - 29557064
AN - SCOPUS:85044185969
VL - 22
JO - Current Pain and Headache Reports
JF - Current Pain and Headache Reports
SN - 1531-3433
M1 - 27
ER -
ID: 200383617