The role of contrast-enhanced endoscopic ultrasound in pancreatic adenocarcinoma
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The role of contrast-enhanced endoscopic ultrasound in pancreatic adenocarcinoma. / Saftoiu, Adrian; Vilmann, Peter; Bhutani, Manoop S.
I: Endoscopic Ultrasound, Bind 5, Nr. 6, 2016, s. 368-372.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The role of contrast-enhanced endoscopic ultrasound in pancreatic adenocarcinoma
AU - Saftoiu, Adrian
AU - Vilmann, Peter
AU - Bhutani, Manoop S
PY - 2016
Y1 - 2016
N2 - Contrast-enhanced endoscopic ultrasound (CE-EUS) allows characterization, differentiation, and staging of focal pancreatic masses. The method has a high sensitivity and specificity for the diagnosis of pancreatic adenocarcinoma which is visualized as hypo-enhanced as compared to the rest of the parenchyma while chronic pancreatitis and neuroendocrine tumors are generally either iso-enhanced or hyper-enhanced. The development of contrast-enhanced low mechanical index harmonic imaging techniques used in real time during endoscopic ultrasound (EUS) allowed perfusion imaging and the quantification of intensity of the contrast signal through time-intensity curve analysis. Thus, contrast harmonic imaging-EUS has been used to differentiate pancreatic adenocarcinoma based on lower values of the peak enhancement. Future applications of CE-EUS in pancreatic adenocarcinoma include not only use of targeted contrast agents for early detection, tridimensional and fusion techniques for enhanced staging and resectability assessment but also novel applications of perfusion imaging for monitoring ablative therapy, improved local detection through EUS-guided sampling of portal vein flow or enhanced drug delivery through sonoporation and ultrasound-induced release of the drugs locally.
AB - Contrast-enhanced endoscopic ultrasound (CE-EUS) allows characterization, differentiation, and staging of focal pancreatic masses. The method has a high sensitivity and specificity for the diagnosis of pancreatic adenocarcinoma which is visualized as hypo-enhanced as compared to the rest of the parenchyma while chronic pancreatitis and neuroendocrine tumors are generally either iso-enhanced or hyper-enhanced. The development of contrast-enhanced low mechanical index harmonic imaging techniques used in real time during endoscopic ultrasound (EUS) allowed perfusion imaging and the quantification of intensity of the contrast signal through time-intensity curve analysis. Thus, contrast harmonic imaging-EUS has been used to differentiate pancreatic adenocarcinoma based on lower values of the peak enhancement. Future applications of CE-EUS in pancreatic adenocarcinoma include not only use of targeted contrast agents for early detection, tridimensional and fusion techniques for enhanced staging and resectability assessment but also novel applications of perfusion imaging for monitoring ablative therapy, improved local detection through EUS-guided sampling of portal vein flow or enhanced drug delivery through sonoporation and ultrasound-induced release of the drugs locally.
KW - Review
KW - Journal Article
U2 - 10.4103/2303-9027.190932
DO - 10.4103/2303-9027.190932
M3 - Review
C2 - 28000627
VL - 5
SP - 368
EP - 372
JO - Endoscopic Ultrasound
JF - Endoscopic Ultrasound
SN - 2226-7190
IS - 6
ER -
ID: 179918291