The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy Study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization : the Copenhagen Allergy Study. / Linneberg, A; Petersen, J; Nielsen, N H; Madsen, F; Frølund, L; Dirksen, A; Jørgensen, T.
I: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Bind 33, Nr. 2, 02.2003, s. 192-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization
T2 - the Copenhagen Allergy Study
AU - Linneberg, A
AU - Petersen, J
AU - Nielsen, N H
AU - Madsen, F
AU - Frølund, L
AU - Dirksen, A
AU - Jørgensen, T
PY - 2003/2
Y1 - 2003/2
N2 - BACKGROUND: Several studies in patient populations have reported a positive association between alcohol consumption and serum total IgE. Furthermore, we have previously reported a positive association between alcohol consumption and the prevalence of skin prick test (SPT positivity) to inhalant allergens in a population-based cross-sectional study.OBJECTIVE: To investigate the relationship of alcohol consumption to levels of serum total IgE and the development of IgE sensitization to inhalant allergens.METHODS: In 1990, self-reported consumption of alcohol, serum total IgE, SPT positivity and specific IgE positivity to inhalant allergens were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Copenhagen, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using multivariable regression analyses.RESULTS: In non-atopic (specific IgE negative) subjects there was a positive association between alcohol consumption and the concentration of total IgE (P = 0.001). During the follow-up period, 45 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. There was no significant association between alcohol consumption and the development of SPT positivity or specific IgE positivity. However, the risk of developing SPT positivity tended to increase with increasing consumption of alcohol (P = 0.055).CONCLUSIONS: This epidemiological study confirms that alcohol consumption has an influence on levels of serum total IgE. A significant association between alcohol consumption and the development of IgE sensitization was not established. However, there seems to be a lack epidemiological data on this issue.
AB - BACKGROUND: Several studies in patient populations have reported a positive association between alcohol consumption and serum total IgE. Furthermore, we have previously reported a positive association between alcohol consumption and the prevalence of skin prick test (SPT positivity) to inhalant allergens in a population-based cross-sectional study.OBJECTIVE: To investigate the relationship of alcohol consumption to levels of serum total IgE and the development of IgE sensitization to inhalant allergens.METHODS: In 1990, self-reported consumption of alcohol, serum total IgE, SPT positivity and specific IgE positivity to inhalant allergens were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Copenhagen, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using multivariable regression analyses.RESULTS: In non-atopic (specific IgE negative) subjects there was a positive association between alcohol consumption and the concentration of total IgE (P = 0.001). During the follow-up period, 45 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. There was no significant association between alcohol consumption and the development of SPT positivity or specific IgE positivity. However, the risk of developing SPT positivity tended to increase with increasing consumption of alcohol (P = 0.055).CONCLUSIONS: This epidemiological study confirms that alcohol consumption has an influence on levels of serum total IgE. A significant association between alcohol consumption and the development of IgE sensitization was not established. However, there seems to be a lack epidemiological data on this issue.
KW - Adolescent
KW - Adult
KW - Aged
KW - Alcohol Drinking
KW - Allergens
KW - Ethanol
KW - Follow-Up Studies
KW - Humans
KW - Hypersensitivity, Immediate
KW - Immunoglobulin E
KW - Linear Models
KW - Middle Aged
KW - Odds Ratio
KW - Skin Tests
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - Journal article
C2 - 12580911
VL - 33
SP - 192
EP - 198
JO - Clinical Allergy
JF - Clinical Allergy
SN - 0954-7894
IS - 2
ER -
ID: 173163647