The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study
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The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study. / Kristensen, Daniel; Nielsen, Lars B; Roug, Anne S; Kristensen, Tove-Christina C; El-Galaly, Tarec C; Nørgaard, Jan M; Marcher, Claus W; Schöllkopf, Claudia; Theilgaard-Mönch, Kim; Severinsen, Marianne T.
I: British Journal of Haematology, Bind 190, Nr. 2, 07.2020, s. 236-243.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study
AU - Kristensen, Daniel
AU - Nielsen, Lars B
AU - Roug, Anne S
AU - Kristensen, Tove-Christina C
AU - El-Galaly, Tarec C
AU - Nørgaard, Jan M
AU - Marcher, Claus W
AU - Schöllkopf, Claudia
AU - Theilgaard-Mönch, Kim
AU - Severinsen, Marianne T
N1 - © 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
PY - 2020/7
Y1 - 2020/7
N2 - With rising life expectancy, the importance of patient-related prognostic factors and how to integrate such data into clinical decision-making becomes increasingly important. The aim of this study was to evaluate the prognostic impact of smoking status in patients with acute myeloid leukaemia (AML) treated with intensive chemotherapy. We conducted a nationwide cohort study based on data obtained from the Danish National Leukaemia Registry (DNLR). The study comprised Danish patients aged 18-75 years, diagnosed with AML between 1 January 2000 and 31 December 2012. Medical records were reviewed and data on smoking status were collected. A total of 1040 patients (median age 59 years) were included, and 602 patients (58·9%) were categorised as ever-smokers and the remaining as never-smokers. Kaplan-Meier survival estimates revealed that ever-smokers had a significant shorter median overall survival (OS) at 17·2 months [95% CI (14·9;19·1)] compared to never-smokers at 24·5 months (95% CI [19·2;30·7]). Multivariate analysis revealed smoking status as a significant prognostic factor for inferior OS with a hazard ratio (HR) of 1·22 [95% CI (1·04;1·44)]. In conclusion, smoking status was found to be associated with inferior OS in intensively treated AML patients.
AB - With rising life expectancy, the importance of patient-related prognostic factors and how to integrate such data into clinical decision-making becomes increasingly important. The aim of this study was to evaluate the prognostic impact of smoking status in patients with acute myeloid leukaemia (AML) treated with intensive chemotherapy. We conducted a nationwide cohort study based on data obtained from the Danish National Leukaemia Registry (DNLR). The study comprised Danish patients aged 18-75 years, diagnosed with AML between 1 January 2000 and 31 December 2012. Medical records were reviewed and data on smoking status were collected. A total of 1040 patients (median age 59 years) were included, and 602 patients (58·9%) were categorised as ever-smokers and the remaining as never-smokers. Kaplan-Meier survival estimates revealed that ever-smokers had a significant shorter median overall survival (OS) at 17·2 months [95% CI (14·9;19·1)] compared to never-smokers at 24·5 months (95% CI [19·2;30·7]). Multivariate analysis revealed smoking status as a significant prognostic factor for inferior OS with a hazard ratio (HR) of 1·22 [95% CI (1·04;1·44)]. In conclusion, smoking status was found to be associated with inferior OS in intensively treated AML patients.
U2 - 10.1111/bjh.16667
DO - 10.1111/bjh.16667
M3 - Journal article
C2 - 32316076
VL - 190
SP - 236
EP - 243
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 2
ER -
ID: 239961232