The post-transcriptional operon
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The post-transcriptional operon. / Tenenbaum, Scott A.; Christiansen, Jan; Nielsen, Henrik.
RNA: methods and protocols. red. / Henrik Nielsen. Springer, 2011. s. 237-245 (Methods in Molecular Biology).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - The post-transcriptional operon
AU - Tenenbaum, Scott A.
AU - Christiansen, Jan
AU - Nielsen, Henrik
PY - 2011
Y1 - 2011
N2 - A post-transcriptional operon is a set of monocistronic mRNAs encoding functionally related proteins that are co-regulated by a group of RNA-binding proteins and/or small non-coding RNAs so that protein expression is coordinated at the post-transcriptional level. The post-transcriptional operon model (PTO) is used to describe data from an assortment of methods (e.g. RIP-Chip, CLIP-Chip, miRNA profiling, ribosome profiling) that globally address the functionality of mRNA. Several examples of post-transcriptional operons have been documented in the literature and demonstrate the usefulness of the model in identifying new participants in cellular pathways as well as in deepening our understanding of cellular responses.
AB - A post-transcriptional operon is a set of monocistronic mRNAs encoding functionally related proteins that are co-regulated by a group of RNA-binding proteins and/or small non-coding RNAs so that protein expression is coordinated at the post-transcriptional level. The post-transcriptional operon model (PTO) is used to describe data from an assortment of methods (e.g. RIP-Chip, CLIP-Chip, miRNA profiling, ribosome profiling) that globally address the functionality of mRNA. Several examples of post-transcriptional operons have been documented in the literature and demonstrate the usefulness of the model in identifying new participants in cellular pathways as well as in deepening our understanding of cellular responses.
KW - Gene Expression Regulation
KW - Models, Genetic
KW - RNA, Messenger
KW - Ribonucleoproteins
U2 - 10.1007/978-1-59745-248-9_16
DO - 10.1007/978-1-59745-248-9_16
M3 - Book chapter
C2 - 21125494
SN - 978-1-58829-913-0
T3 - Methods in Molecular Biology
SP - 237
EP - 245
BT - RNA
A2 - Nielsen, Henrik
PB - Springer
ER -
ID: 33542379