The nickel dose–response relationship by filaggrin genotype (FLG)
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The nickel dose–response relationship by filaggrin genotype (FLG). / Ross-Hansen, Katrine; Johansen, Jeanne D; Vølund, Aage; Menné, Torkil; Thyssen, Jacob P.
I: Contact Dermatitis, Bind 71, Nr. 1, 07.2014, s. 49-53.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The nickel dose–response relationship by filaggrin genotype (FLG)
AU - Ross-Hansen, Katrine
AU - Johansen, Jeanne D
AU - Vølund, Aage
AU - Menné, Torkil
AU - Thyssen, Jacob P
N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2014/7
Y1 - 2014/7
N2 - BACKGROUND: On skin contact, nickel accumulates in the stratum corneum, where it is probably bound to proteins and amino acids. One probable contributor is filaggrin, which binds nickel avidly. Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults.OBJECTIVES: To investigate whether the experimental nickel elicitation threshold level differed between heterozygous FLG mutation and non-mutation carriers.METHOD: Thirteen nickel-sensitized female patients, seven heterozygous mutation carriers and six non-mutation carriers (genotyped for R501X, 2282del4, or R2447X), were patch tested and performed a repeated open application test (ROAT) with a nickel sulfate dilution series. Logistic threshold dose-response analyses were used to test for differences between the two groups.RESULTS: No difference was found in the dose-response relationship between FLG mutation and non-mutation carriers.CONCLUSIONS: On the basis of this small patient study, it appears that the elicitation threshold level for nickel is independent of FLG null mutation single-allele carrier status.
AB - BACKGROUND: On skin contact, nickel accumulates in the stratum corneum, where it is probably bound to proteins and amino acids. One probable contributor is filaggrin, which binds nickel avidly. Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults.OBJECTIVES: To investigate whether the experimental nickel elicitation threshold level differed between heterozygous FLG mutation and non-mutation carriers.METHOD: Thirteen nickel-sensitized female patients, seven heterozygous mutation carriers and six non-mutation carriers (genotyped for R501X, 2282del4, or R2447X), were patch tested and performed a repeated open application test (ROAT) with a nickel sulfate dilution series. Logistic threshold dose-response analyses were used to test for differences between the two groups.RESULTS: No difference was found in the dose-response relationship between FLG mutation and non-mutation carriers.CONCLUSIONS: On the basis of this small patient study, it appears that the elicitation threshold level for nickel is independent of FLG null mutation single-allele carrier status.
KW - Adult
KW - Aged
KW - Dermatitis, Contact
KW - Dose-Response Relationship, Drug
KW - Epidermis
KW - Female
KW - Genotype
KW - Humans
KW - Intermediate Filament Proteins
KW - Irritants
KW - Middle Aged
KW - Mutation
KW - Nickel
KW - Patch Tests
KW - Phosphoproteins
KW - Young Adult
U2 - 10.1111/cod.12228
DO - 10.1111/cod.12228
M3 - Journal article
C2 - 24673390
VL - 71
SP - 49
EP - 53
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 1
ER -
ID: 138620913