The integrin-actin connection, an eternal love affair.
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The integrin-actin connection, an eternal love affair. / Brakebusch, Cord; Fässler, Reinhard.
I: EMBO Journal, Bind 22, Nr. 10, 2003, s. 2324-33.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The integrin-actin connection, an eternal love affair.
AU - Brakebusch, Cord
AU - Fässler, Reinhard
N1 - Keywords: Actinin; Actins; Animals; Carrier Proteins; Cell Adhesion; Cytoskeleton; DNA-Binding Proteins; Extracellular Matrix; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction
PY - 2003
Y1 - 2003
N2 - Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.
AB - Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.
U2 - 10.1093/emboj/cdg245
DO - 10.1093/emboj/cdg245
M3 - Journal article
C2 - 12743027
VL - 22
SP - 2324
EP - 2333
JO - E M B O Journal
JF - E M B O Journal
SN - 0261-4189
IS - 10
ER -
ID: 5141360