TY - JOUR

T1 - The integrin-actin connection, an eternal love affair.

AU - Brakebusch, Cord

AU - Fässler, Reinhard

N1 - Keywords: Actinin; Actins; Animals; Carrier Proteins; Cell Adhesion; Cytoskeleton; DNA-Binding Proteins; Extracellular Matrix; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction

PY - 2003

Y1 - 2003

N2 - Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.

AB - Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.

U2 - 10.1093/emboj/cdg245

DO - 10.1093/emboj/cdg245

M3 - Journal article

C2 - 12743027

VL - 22

SP - 2324

EP - 2333

JO - E M B O Journal

JF - E M B O Journal

SN - 0261-4189

IS - 10

ER -