The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide. / Wolthers, O D; Juul, A; Hansen, M; Müller, J; Pedersen, S.

I: Acta Paediatrica, Bind 84, Nr. 4, 1995, s. 393-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Wolthers, OD, Juul, A, Hansen, M, Müller, J & Pedersen, S 1995, 'The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide', Acta Paediatrica, bind 84, nr. 4, s. 393-7.

APA

Wolthers, O. D., Juul, A., Hansen, M., Müller, J., & Pedersen, S. (1995). The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide. Acta Paediatrica, 84(4), 393-7.

Vancouver

Wolthers OD, Juul A, Hansen M, Müller J, Pedersen S. The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide. Acta Paediatrica. 1995;84(4):393-7.

Author

Wolthers, O D ; Juul, A ; Hansen, M ; Müller, J ; Pedersen, S. / The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide. I: Acta Paediatrica. 1995 ; Bind 84, Nr. 4. s. 393-7.

Bibtex

@article{92ebfe6a0fdf4d5698d9baaf506d4321,
title = "The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide",
abstract = "Serum concentrations of growth hormone-dependent insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3), the carboxy terminal propeptide of type I procollagen (PICP), the carboxy terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) and the amino terminal propeptide of type III procollagen (PIIINP) were studied in 14 prepubertal children with asthma (mean age 9.7 years) during treatment with inhaled budesonide. The study design was a randomized, crossover trial with two double-blind treatment periods (200 and 800 micrograms) and one open, non-randomized treatment period (400 micrograms). All periods were 18 days' duration. Budesonide treatment was associated with a dose-related suppressive trend in serum concentrations of PIIINP when the 400 micrograms period was included (p <0.01; z = -2.7) and when it was excluded from the calculations (p <0.01; z = -2.6), indicating reduced synthesis of type III collagen. A similar trend was observed in ICTP levels when the 400 micrograms period was excluded from the calculations (p = 0.05; z = -1.9). No other statistically significant variations were seen.",
author = "Wolthers, {O D} and A Juul and M Hansen and J M{\"u}ller and S Pedersen",
year = "1995",
language = "English",
volume = "84",
pages = "393--7",
journal = "Acta Paediatrica",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - The insulin-like growth factor axis and collagen turnover in asthmatic children treated with inhaled budesonide

AU - Wolthers, O D

AU - Juul, A

AU - Hansen, M

AU - Müller, J

AU - Pedersen, S

PY - 1995

Y1 - 1995

N2 - Serum concentrations of growth hormone-dependent insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3), the carboxy terminal propeptide of type I procollagen (PICP), the carboxy terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) and the amino terminal propeptide of type III procollagen (PIIINP) were studied in 14 prepubertal children with asthma (mean age 9.7 years) during treatment with inhaled budesonide. The study design was a randomized, crossover trial with two double-blind treatment periods (200 and 800 micrograms) and one open, non-randomized treatment period (400 micrograms). All periods were 18 days' duration. Budesonide treatment was associated with a dose-related suppressive trend in serum concentrations of PIIINP when the 400 micrograms period was included (p <0.01; z = -2.7) and when it was excluded from the calculations (p <0.01; z = -2.6), indicating reduced synthesis of type III collagen. A similar trend was observed in ICTP levels when the 400 micrograms period was excluded from the calculations (p = 0.05; z = -1.9). No other statistically significant variations were seen.

AB - Serum concentrations of growth hormone-dependent insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3), the carboxy terminal propeptide of type I procollagen (PICP), the carboxy terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) and the amino terminal propeptide of type III procollagen (PIIINP) were studied in 14 prepubertal children with asthma (mean age 9.7 years) during treatment with inhaled budesonide. The study design was a randomized, crossover trial with two double-blind treatment periods (200 and 800 micrograms) and one open, non-randomized treatment period (400 micrograms). All periods were 18 days' duration. Budesonide treatment was associated with a dose-related suppressive trend in serum concentrations of PIIINP when the 400 micrograms period was included (p <0.01; z = -2.7) and when it was excluded from the calculations (p <0.01; z = -2.6), indicating reduced synthesis of type III collagen. A similar trend was observed in ICTP levels when the 400 micrograms period was excluded from the calculations (p = 0.05; z = -1.9). No other statistically significant variations were seen.

M3 - Journal article

VL - 84

SP - 393

EP - 397

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 4

ER -

ID: 48486730