The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade

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Standard

The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade. / Bonefeld, Karen; Hobolth, Lise; Juul, Anders; Møller, Søren.

I: Growth Hormone & I G F Research, Bind 22, Nr. 6, 2012, s. 212-218.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bonefeld, K, Hobolth, L, Juul, A & Møller, S 2012, 'The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade', Growth Hormone & I G F Research, bind 22, nr. 6, s. 212-218. https://doi.org/10.1016/j.ghir.2012.09.001

APA

Bonefeld, K., Hobolth, L., Juul, A., & Møller, S. (2012). The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade. Growth Hormone & I G F Research, 22(6), 212-218. https://doi.org/10.1016/j.ghir.2012.09.001

Vancouver

Bonefeld K, Hobolth L, Juul A, Møller S. The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade. Growth Hormone & I G F Research. 2012;22(6):212-218. https://doi.org/10.1016/j.ghir.2012.09.001

Author

Bonefeld, Karen ; Hobolth, Lise ; Juul, Anders ; Møller, Søren. / The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade. I: Growth Hormone & I G F Research. 2012 ; Bind 22, Nr. 6. s. 212-218.

Bibtex

@article{0ad133e3c2104fde9ae9cd81e5fa0e31,

title = "The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade",

abstract = "OBJECTIVE: Circulating levels of IGF-I and IGFBP-3 are low in cirrhosis and are related to liver dysfunction. Metabolic disturbances include malnutrition with altered body composition and osteopenia. Since the effects of IGF-I may be associated to changes in body composition and bone mineral content (BMC) in cirrhotic patients, we investigated the relations between changes in the IGF-system and body composition and the effects of long-term alpha- and beta-blockade. DESIGN: The study was designed as a combined cross-sectional and prospective randomised controlled study of 62 patients with cirrhosis. Twenty-three of these patients were randomised to treatment with beta- or combined alpha/beta-blocker for 3months. Haemodynamics, body composition, and systemic and hepatic IGF-I and IGFBP-3 levels were determined in all patients. In the subgroup changes in body composition and IGF-I/IGFBP-3 levels after 3months of beta- or combined alpha/beta-blockade were additionally examined. RESULTS: Both the hepatic and the systemic IGF systems were suppressed and correlated with liver dysfunction and anthropometrics (p",

author = "Karen Bonefeld and Lise Hobolth and Anders Juul and S{\o}ren M{\o}ller",

year = "2012",

doi = "10.1016/j.ghir.2012.09.001",

language = "English",

volume = "22",

pages = "212--218",

journal = "Growth Hormone & I G F Research",

issn = "1096-6374",

publisher = "Churchill Livingstone",

number = "6",

}

RIS

TY - JOUR

T1 - The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade

AU - Bonefeld, Karen

AU - Hobolth, Lise

AU - Juul, Anders

AU - Møller, Søren

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: Circulating levels of IGF-I and IGFBP-3 are low in cirrhosis and are related to liver dysfunction. Metabolic disturbances include malnutrition with altered body composition and osteopenia. Since the effects of IGF-I may be associated to changes in body composition and bone mineral content (BMC) in cirrhotic patients, we investigated the relations between changes in the IGF-system and body composition and the effects of long-term alpha- and beta-blockade. DESIGN: The study was designed as a combined cross-sectional and prospective randomised controlled study of 62 patients with cirrhosis. Twenty-three of these patients were randomised to treatment with beta- or combined alpha/beta-blocker for 3months. Haemodynamics, body composition, and systemic and hepatic IGF-I and IGFBP-3 levels were determined in all patients. In the subgroup changes in body composition and IGF-I/IGFBP-3 levels after 3months of beta- or combined alpha/beta-blockade were additionally examined. RESULTS: Both the hepatic and the systemic IGF systems were suppressed and correlated with liver dysfunction and anthropometrics (p

AB - OBJECTIVE: Circulating levels of IGF-I and IGFBP-3 are low in cirrhosis and are related to liver dysfunction. Metabolic disturbances include malnutrition with altered body composition and osteopenia. Since the effects of IGF-I may be associated to changes in body composition and bone mineral content (BMC) in cirrhotic patients, we investigated the relations between changes in the IGF-system and body composition and the effects of long-term alpha- and beta-blockade. DESIGN: The study was designed as a combined cross-sectional and prospective randomised controlled study of 62 patients with cirrhosis. Twenty-three of these patients were randomised to treatment with beta- or combined alpha/beta-blocker for 3months. Haemodynamics, body composition, and systemic and hepatic IGF-I and IGFBP-3 levels were determined in all patients. In the subgroup changes in body composition and IGF-I/IGFBP-3 levels after 3months of beta- or combined alpha/beta-blockade were additionally examined. RESULTS: Both the hepatic and the systemic IGF systems were suppressed and correlated with liver dysfunction and anthropometrics (p

U2 - 10.1016/j.ghir.2012.09.001

DO - 10.1016/j.ghir.2012.09.001

M3 - Journal article

C2 - 23031335

VL - 22

SP - 212

EP - 218

JO - Growth Hormone & I G F Research

JF - Growth Hormone & I G F Research

SN - 1096-6374

IS - 6

ER -

ID: 48487402