The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Phthalates are ubiquitous environmental chemicals with predominantly anti-androgenic, and potentially obesogenic effects. We hypothesised that antenatal phthalate exposure may influence subsequent boy's growth and body composition through childhood and adolescence. Among 1399 singleton males from the Raine Study, 410 had maternal serum and at least one height, BMI or DEXA outcome available after birth and up to 20 years of age. Maternal serum collected at 18 and 34 weeks' gestation was pooled, and analyzed for concentrations of 32 metabolites of 15 phthalate diesters. Their serum concentrations were categorized into undetectable/detectable levels or tertiles. Linear mixed models were used to determine associations between maternal serum phthalate levels and longitudinal height and body mass index (BMI) z-scores in boys from birth to 20 years of age (n = 250 and n = 295 respectively). Linear regression was used to determine associations between maternal phthalate levels and deviation from mid-parental height (n = 177) and DEXA scan outcomes (n = 191) at the 20 year follow-up. Weak positive associations of participants height z-score increase were detected with exposure to some phthalate metabolites in particular to the lower molecular weight phthalate metabolites. Less consistent findings, by mixed model analyses, were detected for BMI and body composition, by dual energy X-ray absorptiometry (DEXA), with some positive associations of phthalate metabolites with BMI and some negative associations with DEXA fat tissue measures, although no consistent findings were evident. In conclusion, we derived some associations of childhood growth with prenatal phthalate exposure, particularly with respect to the lower molecular weight phthalate metabolites.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 110313 |
| Tidsskrift | Environmental Research |
| Vol/bind | 195 |
| Antal sider | 9 |
| ISSN | 0013-9351 |
| DOI | |
| Status | Udgivet - apr. 2021 |
Bibliografisk note
Funding Information:
The collection of maternal data and samples was funded by NH&MRC, the Raine Medical Research Foundation and The Women and Infants Research Foundation (WIRF). This study received infrastructure funding from the Western Australian Health Department, an educational grant from Ferring pharmaceuticals and EDMaRC ( www.edmarc.net ), and received core management funding and support from the Raine Medical Research Foundation, The Telethon Kids institute, The University of Western Australia, UWA Faculty of Medicine, Dentistry and Health Sciences, Women and Infant Research Foundation, Curtin University and Edith Cowan University.
Funding Information:
We are extremely grateful to the Raine Study participants and their families who took part in this study, the Raine Study Team for cohort co-ordination and data collection, the NH&MRC for their long term contribution to funding the study over the last 30 years and the Telethon Institute for Child Health Research for long term support of the Study. We acknowledge the Raine Medical Research Foundation, The Telethon Kids Institute, The University of Western Australia (UWA), UWA Faculty of Medicine, Dentistry and Health Sciences, Women's and Infant's Research Foundation, Edith Cowan University, Murdoch University, The University of Notre Dame and Curtin University for financial support and for providing funding for core management of the Raine Study. We acknowledge the UWA School of Women's and Infants' Health, King Edward Memorial Hospital, the UWA Medical School, Royal Perth Hospital and Telethon Kids Institute for in-kind support provided for biosample storage and curation.
Funding Information:
We are extremely grateful to the Raine Study participants and their families who took part in this study, the Raine Study Team for cohort co-ordination and data collection, the NH&MRC for their long term contribution to funding the study over the last 30 years and the Telethon Institute for Child Health Research for long term support of the Study. We acknowledge the Raine Medical Research Foundation, The Telethon Kids Institute, The University of Western Australia (UWA), UWA Faculty of Medicine, Dentistry and Health Sciences, Women's and Infant's Research Foundation, Edith Cowan University, Murdoch University, The University of Notre Dame and Curtin University for financial support and for providing funding for core management of the Raine Study. We acknowledge the UWA School of Women's and Infants' Health, King Edward Memorial Hospital, the UWA Medical School, Royal Perth Hospital and Telethon Kids Institute for in-kind support provided for biosample storage and curation.
Publisher Copyright:
© 2020 Elsevier Inc.
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