The Impact of Maternal Age on the Neonatal Electrocardiogram
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Previous studies have suggested an increased prevalence of congenital heart disease among children born to women aged ≥35 years. In recent decades, the mother's age at childbirth has increased dramatically in industrialized countries. It has not been investigated if increasing maternal age affects the neonatal cardiac electrical system. Methods: The Copenhagen Baby Heart Study is a prospective general population study that performed cardiac evaluation in newborns. Electrocardiograms were analyzed with a computerized algorithm. Results: We included 16,518 newborns with normal echocardiograms (median age 11 days; range 0-30 days; 52% boys). Median maternal age at delivery was 31 years; 790 newborns were born to mothers aged between 16 and 24 years, 11,403 between 25 and 34 years, 4,279 between 35 and 44 years, and 46 newborns had mothers aged between 45 and 54 years. The QRS axis and maximum R-wave amplitude in V1 (R-V1) differed across the four maternal age groups (both p < 0.01), with absolute differences of 3.5% (114 vs. 110°) and 12% (1,152 vs. 1,015 μV), respectively, between newborns with the youngest and oldest mothers. Associations between maternal age and the QRS axis and R-V1 remained significant after multifactorial adjustment. Heart rate, PR interval, QRS duration, uncorrected QT interval, QTcBazett, and maximum amplitudes of S-V1, R-V6, and S-V6 were not associated with maternal age (all p > 0.05). Conclusion: We observed a significant association between maternal age and the neonatal QRS axis and R-V1. However, the absolute differences were relatively small and maternal age is unlikely to have a clinically significant effect on the neonatal cardiac electrical system.
Originalsprog | Engelsk |
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Tidsskrift | Neonatology |
Vol/bind | 119 |
Udgave nummer | 5 |
Sider (fra-til) | 629-637 |
ISSN | 1661-7800 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This work was supported by the Danish Heart Foundation (Grant 20-R140-A9569-22168, MMP), the Danish Children Heart Foundation (Grant 19-R112-A5248-26048, MMP), Snedkermester Sophus Jacobsen and wife Astrid Jacobsen’s foundation, The Research Council at Herlev-Gentofte Hospital, The Health Foundation Denmark, The Independent Research Fund Denmark (Grant 0134-00363B, AHC), Novo Nordisk Foundation Denmark, Candy’s Foundation, and The Toyota Foundation, Denmark. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
This work was supported by the Danish Heart Foundation (Grant 20-R140-A9569-22168, MMP), the Danish Children Heart Foundation (Grant 19-R112-A5248-26048, MMP), Snedkermester Sophus Jacobsen and wife Astrid Jacobsen's foundation, The Research Council at Herlev-Gentofte Hospital, The Health Foundation Denmark, The Independent Research Fund Denmark (Grant 0134-00363B, AHC), Novo Nordisk Foundation Denmark, Candy's Foundation, and The Toyota Foundation, Denmark
Publisher Copyright:
© 2022
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