The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men
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The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men. / Haugaard, S B; Andersen, O; Hansen, T W; Eugen-Olsen, J; Linneberg, A; Madsbad, S; Olsen, M H; Jørgensen, T; Borch-Johnsen, Knut; Jeppesen, J.
I: Diabetic Medicine, Bind 29, Nr. 4, 2012, s. 479-487.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The immune marker soluble urokinase plasminogen activator receptor is associated with new-onset diabetes in non-smoking women and men
AU - Haugaard, S B
AU - Andersen, O
AU - Hansen, T W
AU - Eugen-Olsen, J
AU - Linneberg, A
AU - Madsbad, S
AU - Olsen, M H
AU - Jørgensen, T
AU - Borch-Johnsen, Knut
AU - Jeppesen, J
N1 - Journal compilation © 2011 Diabetes UK.
PY - 2012
Y1 - 2012
N2 - Aim: To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation. This association has been previously suggested by using the less sensitive International Classification of Disease system to detect incident diabetes in the Danish MONICA 10 cohort. Methods: The Danish National Diabetes Register enabled more accurate identification of incident diabetes during a median follow-up of 13.8 years in the Danish MONICA 10 cohort (n = 2353 generally healthy individuals). The soluble urokinase plasminogen activator receptor was measured by the ELISA method. To fulfil model assumptions, outcome analyses were stratified by age, and further by smoking, owing to the interaction between the soluble urokinase plasminogen activator receptor and smoking on new-onset diabetes (P
AB - Aim: To explore the putative association of new-onset diabetes and the soluble urokinase plasminogen activator receptor (suPAR), which is a new and stable plasma marker of immune function and low-grade inflammation. This association has been previously suggested by using the less sensitive International Classification of Disease system to detect incident diabetes in the Danish MONICA 10 cohort. Methods: The Danish National Diabetes Register enabled more accurate identification of incident diabetes during a median follow-up of 13.8 years in the Danish MONICA 10 cohort (n = 2353 generally healthy individuals). The soluble urokinase plasminogen activator receptor was measured by the ELISA method. To fulfil model assumptions, outcome analyses were stratified by age, and further by smoking, owing to the interaction between the soluble urokinase plasminogen activator receptor and smoking on new-onset diabetes (P
U2 - 10.1111/j.1464-5491.2011.03513.x
DO - 10.1111/j.1464-5491.2011.03513.x
M3 - Journal article
C2 - 22050462
VL - 29
SP - 479
EP - 487
JO - Diabetic Medicine
JF - Diabetic Medicine
SN - 0742-3071
IS - 4
ER -
ID: 40140115