The homeostatic astroglia emerges from evolutionary specialization of neural cells
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The homeostatic astroglia emerges from evolutionary specialization of neural cells. / Verkhratsky, Alexei; Nedergaard, Maiken.
I: Royal Society of London. Philosophical Transactions B. Biological Sciences, Bind 371, Nr. 1700, 20150428, 05.08.2016, s. 1-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The homeostatic astroglia emerges from evolutionary specialization of neural cells
AU - Verkhratsky, Alexei
AU - Nedergaard, Maiken
N1 - © 2016 The Author(s).
PY - 2016/8/5
Y1 - 2016/8/5
N2 - Evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed from electrically excitable neuronal networks connected with chemical synapses and non-excitable glial cells that provide for homeostasis and defence. Astrocytes are integrated into neural networks through multipartite synapses; astroglial perisynaptic processes closely enwrap synaptic contacts and control homeostasis of the synaptic cleft, supply neurons with glutamate and GABA obligatory precursor glutamine and contribute to synaptic plasticity, learning and memory. In neuropathology, astrocytes may undergo reactive remodelling or degeneration; to a large extent, astroglial reactions define progression of the pathology and neurological outcome.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.
AB - Evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed from electrically excitable neuronal networks connected with chemical synapses and non-excitable glial cells that provide for homeostasis and defence. Astrocytes are integrated into neural networks through multipartite synapses; astroglial perisynaptic processes closely enwrap synaptic contacts and control homeostasis of the synaptic cleft, supply neurons with glutamate and GABA obligatory precursor glutamine and contribute to synaptic plasticity, learning and memory. In neuropathology, astrocytes may undergo reactive remodelling or degeneration; to a large extent, astroglial reactions define progression of the pathology and neurological outcome.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.
KW - Journal Article
KW - Review
U2 - 10.1098/rstb.2015.0428
DO - 10.1098/rstb.2015.0428
M3 - Journal article
C2 - 27377722
VL - 371
SP - 1
EP - 11
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0962-8436
IS - 1700
M1 - 20150428
ER -
ID: 164971726