The External Genitalia Score (EGS): A European Multicenter Validation Study
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The External Genitalia Score (EGS) : A European Multicenter Validation Study. / van der Straaten, Saskia; Springer, Alexander; Zecic, Aleksandra; Hebenstreit, Doris; Tonnhofer, Ursula; Gawlik, Aneta; Baumert, Malgorzata; Szeliga, Kamila; Debulpaep, Sara; Desloovere, An; Tack, Lloyd; Smets, Koen; Wasniewska, Malgorzata; Corica, Domenico; Calafiore, Mariarosa; Ljubicic, Marie Lindhardt; Busch, Alexander Siegfried; Juul, Anders; Nordenström, Anna; Sigurdsson, Jon; Flück, Christa E; Haamberg, Tanja; Graf, Stefanie; Hannema, Sabine E; Wolffenbuttel, Katja P; Hiort, Olaf; Ahmed, S Faisal; Cools, Martine.
I: Journal of Clinical Endocrinology and Metabolism, Bind 105, Nr. 3, 2020, s. e222–e230.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The External Genitalia Score (EGS)
T2 - A European Multicenter Validation Study
AU - van der Straaten, Saskia
AU - Springer, Alexander
AU - Zecic, Aleksandra
AU - Hebenstreit, Doris
AU - Tonnhofer, Ursula
AU - Gawlik, Aneta
AU - Baumert, Malgorzata
AU - Szeliga, Kamila
AU - Debulpaep, Sara
AU - Desloovere, An
AU - Tack, Lloyd
AU - Smets, Koen
AU - Wasniewska, Malgorzata
AU - Corica, Domenico
AU - Calafiore, Mariarosa
AU - Ljubicic, Marie Lindhardt
AU - Busch, Alexander Siegfried
AU - Juul, Anders
AU - Nordenström, Anna
AU - Sigurdsson, Jon
AU - Flück, Christa E
AU - Haamberg, Tanja
AU - Graf, Stefanie
AU - Hannema, Sabine E
AU - Wolffenbuttel, Katja P
AU - Hiort, Olaf
AU - Ahmed, S Faisal
AU - Cools, Martine
N1 - © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2020
Y1 - 2020
N2 - CONTEXT: Standardized description of external genitalia is needed in the assessment of children with atypical genitalia.OBJECTIVES: To validate the External Genitalia Score (EGS), to present reference values for preterm and term babies up to 24 months and correlate obtained scores with anogenital distances (AGDs).DESIGN, SETTING: A European multicenter (n = 8) validation study was conducted from July 2016 to July 2018.PATIENTS AND METHODS: EGS is based on the external masculinization score but uses a gradual scale from female to male (range, 0-12) and terminology appropriate for both sexes. The reliability of EGS and AGDs was determined by the interclass correlation coefficient (ICC). Cross-sectional data were obtained in 686 term babies (0-24 months) and 181 preterm babies, and 111 babies with atypical genitalia.RESULTS: The ICC of EGS in typical and atypical genitalia is excellent and good, respectively. Median EGS (10th to 90th centile) in males < 28 weeks gestation is 10 (8.6-11.5); in males 28-32 weeks 11.5 (9.2-12); in males 33-36 weeks 11.5 (10.5-12) and in full-term males 12 (10.5-12). In all female babies, EGS is 0 (0-0). The mean (SD) lower/upper AGD ratio (AGDl/u) is 0.45 (0.1), with significant difference between AGDl/u in males 0.49 (0.1) and females 0.39 (0.1) and intermediate values in differences of sex development (DSDs) 0.43 (0.1). The AGDl/u correlates with EGS in males with typical genitalia and in atypical genitalia.CONCLUSIONS: EGS is a reliable and valid tool to describe external genitalia in premature and term babies up to 24 months. EGS correlates with AGDl/u in males. It facilitates standardized assessment, clinical decision-making and multicenter research.
AB - CONTEXT: Standardized description of external genitalia is needed in the assessment of children with atypical genitalia.OBJECTIVES: To validate the External Genitalia Score (EGS), to present reference values for preterm and term babies up to 24 months and correlate obtained scores with anogenital distances (AGDs).DESIGN, SETTING: A European multicenter (n = 8) validation study was conducted from July 2016 to July 2018.PATIENTS AND METHODS: EGS is based on the external masculinization score but uses a gradual scale from female to male (range, 0-12) and terminology appropriate for both sexes. The reliability of EGS and AGDs was determined by the interclass correlation coefficient (ICC). Cross-sectional data were obtained in 686 term babies (0-24 months) and 181 preterm babies, and 111 babies with atypical genitalia.RESULTS: The ICC of EGS in typical and atypical genitalia is excellent and good, respectively. Median EGS (10th to 90th centile) in males < 28 weeks gestation is 10 (8.6-11.5); in males 28-32 weeks 11.5 (9.2-12); in males 33-36 weeks 11.5 (10.5-12) and in full-term males 12 (10.5-12). In all female babies, EGS is 0 (0-0). The mean (SD) lower/upper AGD ratio (AGDl/u) is 0.45 (0.1), with significant difference between AGDl/u in males 0.49 (0.1) and females 0.39 (0.1) and intermediate values in differences of sex development (DSDs) 0.43 (0.1). The AGDl/u correlates with EGS in males with typical genitalia and in atypical genitalia.CONCLUSIONS: EGS is a reliable and valid tool to describe external genitalia in premature and term babies up to 24 months. EGS correlates with AGDl/u in males. It facilitates standardized assessment, clinical decision-making and multicenter research.
KW - Cross-Sectional Studies
KW - Disorders of Sex Development/diagnosis
KW - Europe
KW - Female
KW - Genitalia, Female/anatomy & histology
KW - Genitalia, Male/anatomy & histology
KW - Gestational Age
KW - Humans
KW - Infant, Newborn
KW - Infant, Premature
KW - Male
KW - Reference Values
KW - Reproducibility of Results
U2 - 10.1210/clinem/dgz142
DO - 10.1210/clinem/dgz142
M3 - Journal article
C2 - 31665438
VL - 105
SP - e222–e230
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -
ID: 259057458