The epidemic of methylisothiazolinone: a European prospective study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The epidemic of methylisothiazolinone : a European prospective study. / Schwensen, Jakob F.; Uter, Wolfgang; Bruze, Magnus; Svedman, Cecilia; Goossens, An; Wilkinson, Mark; Giménez Arnau, Ana; Gonçalo, Margarida; Andersen, Klaus E.; Paulsen, Evy; Agner, Tove; Foti, Caterina; Aalto-Korte, Kristiina; McFadden, John; White, Ian; Johansen, Jeanne D.
I: Contact Dermatitis, Bind 76, Nr. 5, 05.2017, s. 272-279.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The epidemic of methylisothiazolinone
T2 - a European prospective study
AU - Schwensen, Jakob F.
AU - Uter, Wolfgang
AU - Bruze, Magnus
AU - Svedman, Cecilia
AU - Goossens, An
AU - Wilkinson, Mark
AU - Giménez Arnau, Ana
AU - Gonçalo, Margarida
AU - Andersen, Klaus E.
AU - Paulsen, Evy
AU - Agner, Tove
AU - Foti, Caterina
AU - Aalto-Korte, Kristiina
AU - McFadden, John
AU - White, Ian
AU - Johansen, Jeanne D.
PY - 2017/5
Y1 - 2017/5
N2 - Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Methods: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.). Results: A total of 6.0% (205/3434; range 2.6–13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms. Conclusion: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.
AB - Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Methods: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.). Results: A total of 6.0% (205/3434; range 2.6–13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms. Conclusion: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.
KW - allergic contact dermatitis
KW - CAS no. 2682-20-4
KW - cosmetics
KW - exposure
KW - methylchloroisothiazolinone
KW - methylisothiazolinone
U2 - 10.1111/cod.12733
DO - 10.1111/cod.12733
M3 - Journal article
C2 - 28032337
AN - SCOPUS:85007414683
VL - 76
SP - 272
EP - 279
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 5
ER -
ID: 196142098