TY - JOUR

T1 - The effect of saffron supplementation on glycemic parameters

T2 - An overview of systematic reviews

AU - Sadigi, Behnam

AU - Yarani, Reza

AU - Mirghafourvand, Mojgan

AU - Travica, Nikolaj

AU - Yousefi, Zahra

AU - Shakouri, Seyed Kazem

AU - Ostadrahimi, Alireza

AU - Mobasseri, Majid

AU - Pociot, Flemming

AU - Sanaie, Sarvin

AU - Araj-Khodaei, Mostafa

N1 - Publisher Copyright: © 2022 John Wiley & Sons Ltd.

PY - 2022

Y1 - 2022

N2 - Due to the widespread use of herbal medicine and evidence pointing to the health benefits of saffron supplementation, this review was performed to evaluate the effects of saffron supplementation on glycemic parameters and lipid profiles based on previous reviews. Relevant articles were retrieved from various databases, which included PubMed, Scopus, ProQuest, Web of Science, Embase, and Cochrane until 2020, with no date restrictions. The quality of the included reviews was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist. Finally, of 877 obtained articles, eight reviews meeting the inclusion criteria were included for analysis. Among the eight included reviews, seven articles were meta-analyses. In addition, one review had an average quality while seven had a good quality. A narrative description of the included reviews was performed, while a network meta-analysis was not conducted. A brief review of the results was reported according to the weighted mean difference and mean difference. Seven included reviews assessed the effects of saffron or crocin supplementation on glycemic parameters, and six examined these effects on lipid profile parameters. Almost half of the articles reported significant effects of these supplements on glycemic parameters and lipid profiles. Taken together, results suggest that saffron supplementation may improve glycemic and lipid profile parameters; however, further high-quality studies are needed to confirm the clinical efficacy of saffron on glycemic parameters and lipid profiles.

AB - Due to the widespread use of herbal medicine and evidence pointing to the health benefits of saffron supplementation, this review was performed to evaluate the effects of saffron supplementation on glycemic parameters and lipid profiles based on previous reviews. Relevant articles were retrieved from various databases, which included PubMed, Scopus, ProQuest, Web of Science, Embase, and Cochrane until 2020, with no date restrictions. The quality of the included reviews was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist. Finally, of 877 obtained articles, eight reviews meeting the inclusion criteria were included for analysis. Among the eight included reviews, seven articles were meta-analyses. In addition, one review had an average quality while seven had a good quality. A narrative description of the included reviews was performed, while a network meta-analysis was not conducted. A brief review of the results was reported according to the weighted mean difference and mean difference. Seven included reviews assessed the effects of saffron or crocin supplementation on glycemic parameters, and six examined these effects on lipid profile parameters. Almost half of the articles reported significant effects of these supplements on glycemic parameters and lipid profiles. Taken together, results suggest that saffron supplementation may improve glycemic and lipid profile parameters; however, further high-quality studies are needed to confirm the clinical efficacy of saffron on glycemic parameters and lipid profiles.

KW - Crocin

KW - glycemic parameters

KW - lipid profile

KW - overview

KW - saffron

U2 - 10.1002/ptr.7542

DO - 10.1002/ptr.7542

M3 - Review

C2 - 35778993

AN - SCOPUS:85133175249

VL - 36

SP - 3444

EP - 3458

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 9

ER -