The effect of positive symptoms on social cognition in first-episode schizophrenia is modified by the presence of negative symptoms
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The effect of positive symptoms on social cognition in first-episode schizophrenia is modified by the presence of negative symptoms. / Bliksted, Vibeke; Videbech, Poul; Fagerlund, Birgitte; Frith, Chris.
I: Neuropsychology, Bind 31, Nr. 2, 2017, s. 209-219.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The effect of positive symptoms on social cognition in first-episode schizophrenia is modified by the presence of negative symptoms
AU - Bliksted, Vibeke
AU - Videbech, Poul
AU - Fagerlund, Birgitte
AU - Frith, Chris
N1 - (c) 2017 APA, all rights reserved).
PY - 2017
Y1 - 2017
N2 - OBJECTIVE: There is considerable evidence that patients with schizophrenia have neurocognitive and social-cognitive deficits. It is unclear how such deficits in first-episode schizophrenia relate to current clinical symptoms.METHOD: Fifty-nine patients with first-episode schizophrenia (FES) were tested using the Danish version of NART (premorbid IQ), subtests from WAIS-III (current IQ), and global cognition using Brief Assessment of Cognition in Schizophrena (BACS), a neurocognitive test battery. Social perception was tested using film clips of everyday interactions (TASIT). Theory of mind (ToM) was tested using silent animations (Animated Triangles Task). The FES subjects had been experiencing psychotic symptoms for several years (mean duration 9.5 years 95% confidence interval (CI [7.6;11.3]). The FES patients were divided into clinical subgroups based on their level of positive and negative symptoms (using SANS and SAPS). Healthy controls were matched to the patients.RESULTS: High levels of negative symptoms were associated with low estimated functional IQ and poor neurocognition and social cognition. All SANS subscales, but Avolition-Apathy, had significant negative impact on social cognition. The effects of positive symptoms were complex. High levels of delusions were associated with higher premorbid IQ. In the presence of high levels of negative symptoms, high levels of positive symptoms were associated with the most comprehensive deficits in social perception, while, in the absence of negative symptoms, high levels of positive symptoms were not associated with such deficits.CONCLUSION: The results suggest that social-cognitive training will need to take account of the above mentioned effects of symptoms. (PsycINFO Database Record
AB - OBJECTIVE: There is considerable evidence that patients with schizophrenia have neurocognitive and social-cognitive deficits. It is unclear how such deficits in first-episode schizophrenia relate to current clinical symptoms.METHOD: Fifty-nine patients with first-episode schizophrenia (FES) were tested using the Danish version of NART (premorbid IQ), subtests from WAIS-III (current IQ), and global cognition using Brief Assessment of Cognition in Schizophrena (BACS), a neurocognitive test battery. Social perception was tested using film clips of everyday interactions (TASIT). Theory of mind (ToM) was tested using silent animations (Animated Triangles Task). The FES subjects had been experiencing psychotic symptoms for several years (mean duration 9.5 years 95% confidence interval (CI [7.6;11.3]). The FES patients were divided into clinical subgroups based on their level of positive and negative symptoms (using SANS and SAPS). Healthy controls were matched to the patients.RESULTS: High levels of negative symptoms were associated with low estimated functional IQ and poor neurocognition and social cognition. All SANS subscales, but Avolition-Apathy, had significant negative impact on social cognition. The effects of positive symptoms were complex. High levels of delusions were associated with higher premorbid IQ. In the presence of high levels of negative symptoms, high levels of positive symptoms were associated with the most comprehensive deficits in social perception, while, in the absence of negative symptoms, high levels of positive symptoms were not associated with such deficits.CONCLUSION: The results suggest that social-cognitive training will need to take account of the above mentioned effects of symptoms. (PsycINFO Database Record
KW - Adolescent
KW - Adult
KW - Delusions/diagnosis
KW - Female
KW - Hallucinations/diagnosis
KW - Humans
KW - Male
KW - Mood Disorders/diagnosis
KW - Neuropsychological Tests
KW - Psychiatric Status Rating Scales/statistics & numerical data
KW - Psychometrics/statistics & numerical data
KW - Schizophrenia/diagnosis
KW - Schizophrenic Psychology
KW - Social Behavior Disorders/diagnosis
KW - Social Perception
KW - Statistics as Topic
KW - Theory of Mind
KW - Young Adult
U2 - 10.1037/neu0000309
DO - 10.1037/neu0000309
M3 - Journal article
C2 - 27808537
VL - 31
SP - 209
EP - 219
JO - Neuropsychology
JF - Neuropsychology
SN - 0894-4105
IS - 2
ER -
ID: 194915586