The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism
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The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. / Madsen, Claus Desler; Lykke, Anne; Rasmussen, Lene Juel.
I: Journal of Nucleic Acids, Bind 2010, 01.01.2010.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism
AU - Madsen, Claus Desler
AU - Lykke, Anne
AU - Rasmussen, Lene Juel
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.
AB - Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.
U2 - 10.4061/2010/701518
DO - 10.4061/2010/701518
M3 - Journal article
C2 - 20862377
VL - 2010
JO - Journal of Nucleic Acids
JF - Journal of Nucleic Acids
SN - 2090-0201
ER -
ID: 33489920