The distribution of blood group antigens in experimentally produced carcinomas of rat palate
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The distribution of blood group antigens in experimentally produced carcinomas of rat palate. / Reibel, J; Philipsen, H P; Fisker, A V; Dabelsteen, Erik.
I: Journal of Oral Pathology, Bind 15, Nr. 10, 11.1986, s. 547-51.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The distribution of blood group antigens in experimentally produced carcinomas of rat palate
AU - Reibel, J
AU - Philipsen, H P
AU - Fisker, A V
AU - Dabelsteen, Erik
PY - 1986/11
Y1 - 1986/11
N2 - It has been shown previously that rat oral epithelia express antigens cross-reacting with antibodies against human blood group antigen B and its structural precursor, the H antigen (Type 2 chain). In the present study we investigated the expression of these antigens in malignant changes in the rat palate induced by a chemical carcinogen (4NQO). The H antigen, normally expressed on spinous cells in rats, was absent in malignant epithelium, whereas staining for the B antigen, normally expressed on basal cells, was variable. These changes are equivalent to those seen in human squamous cell carcinomas. The blood group antigen staining pattern in experimentally produced verrucous carcinomas showed an almost normal blood group antigen expression. This may have diagnostic significance. Localized areas of hyperplastic palatal epithelium with slight dysplasia revealed loss of H antigen and the presence of B antigen in suprabasal strata equivalent to the pattern seen in human premalignant epithelium. We conclude from these findings, that the rat model is well suited to study changes in cell surface carbohydrates during chemical carcinogenesis.
AB - It has been shown previously that rat oral epithelia express antigens cross-reacting with antibodies against human blood group antigen B and its structural precursor, the H antigen (Type 2 chain). In the present study we investigated the expression of these antigens in malignant changes in the rat palate induced by a chemical carcinogen (4NQO). The H antigen, normally expressed on spinous cells in rats, was absent in malignant epithelium, whereas staining for the B antigen, normally expressed on basal cells, was variable. These changes are equivalent to those seen in human squamous cell carcinomas. The blood group antigen staining pattern in experimentally produced verrucous carcinomas showed an almost normal blood group antigen expression. This may have diagnostic significance. Localized areas of hyperplastic palatal epithelium with slight dysplasia revealed loss of H antigen and the presence of B antigen in suprabasal strata equivalent to the pattern seen in human premalignant epithelium. We conclude from these findings, that the rat model is well suited to study changes in cell surface carbohydrates during chemical carcinogenesis.
KW - 4-Nitroquinoline-1-oxide
KW - ABO Blood-Group System
KW - Animals
KW - Carcinoma, Papillary
KW - Carcinoma, Squamous Cell
KW - Disease Models, Animal
KW - Immunologic Techniques
KW - Palatal Neoplasms
KW - Rats
M3 - Journal article
C2 - 3104563
VL - 15
SP - 547
EP - 551
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
SN - 0300-9777
IS - 10
ER -
ID: 119594345