TY - JOUR

T1 - The Danish HIV Birth Cohort (DHBC) - A nationwide, prospective cohort

AU - Weis, Nina

AU - Katzenstein, Terese L.

AU - Ørbæk, Mathilde

AU - Storgaard, Merete

AU - Pedersen, Gitte

AU - Johansen, Isik S.

AU - Moseholm, Ellen

N1 - Publisher Copyright: ©

PY - 2021

Y1 - 2021

N2 - Purpose The purpose of the Danish HIV Birth Cohort (DHBC) is to investigate the significance of HIV-1 infection in pregnancy and after delivery in women living with HIV (WLWH) in Denmark and their children, in the era of antiretroviral therapy and other interventions for treatment and prophylaxis. Participants All WLWH giving birth to one or more children in Denmark after 31 December 1999 are included, with consecutive ongoing enrolment, if they are living with HIV and pregnant, or if they are diagnosed with HIV in relation to pregnancy, delivery or shortly after delivery. Findings to date DHBC has been used to describe trends in the management of pregnancies in WLWH and their outcomes on a nationwide basis, mode of delivery and predictors of emergency caesarean section as well as risk factors during pregnancy in WLWH for birth-related complications compared with women from the general population (WGP). We have found that HIV-exposed, but uninfected (HEU) children born to WLWH had a lower median birth weight and gestational age and were at higher risk of intrauterine growth retardation than children born to WGP. We have investigated risk of in-hospital admission and use of antibiotics during the first 4 years of life among HEU children and showed that HEU children had an increased risk of overall hospital admission compared with a matched control group of unexposed children. Further, we compared anthropometric outcomes in children with a matched control group of children not exposed to HIV. Future plans To continuously investigate the significance of HIV infection and antiretroviral therapy in pregnancy and after delivery in WLWH in Denmark and their HEU children and compare these findings with children born to WGP.

AB - Purpose The purpose of the Danish HIV Birth Cohort (DHBC) is to investigate the significance of HIV-1 infection in pregnancy and after delivery in women living with HIV (WLWH) in Denmark and their children, in the era of antiretroviral therapy and other interventions for treatment and prophylaxis. Participants All WLWH giving birth to one or more children in Denmark after 31 December 1999 are included, with consecutive ongoing enrolment, if they are living with HIV and pregnant, or if they are diagnosed with HIV in relation to pregnancy, delivery or shortly after delivery. Findings to date DHBC has been used to describe trends in the management of pregnancies in WLWH and their outcomes on a nationwide basis, mode of delivery and predictors of emergency caesarean section as well as risk factors during pregnancy in WLWH for birth-related complications compared with women from the general population (WGP). We have found that HIV-exposed, but uninfected (HEU) children born to WLWH had a lower median birth weight and gestational age and were at higher risk of intrauterine growth retardation than children born to WGP. We have investigated risk of in-hospital admission and use of antibiotics during the first 4 years of life among HEU children and showed that HEU children had an increased risk of overall hospital admission compared with a matched control group of unexposed children. Further, we compared anthropometric outcomes in children with a matched control group of children not exposed to HIV. Future plans To continuously investigate the significance of HIV infection and antiretroviral therapy in pregnancy and after delivery in WLWH in Denmark and their HEU children and compare these findings with children born to WGP.

KW - epidemiology

KW - HIV & AIDS

KW - reproductive medicine

U2 - 10.1136/bmjopen-2020-044565

DO - 10.1136/bmjopen-2020-044565

M3 - Journal article

C2 - 34244252

AN - SCOPUS:85109707681

VL - 11

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 7

M1 - e044565

ER -