The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders. / Borbye-Lorenzen, Nis; Zhu, Zhihong; Agerbo, Esben; Albiñana, Clara; Benros, Michael E.; Bian, Beilei; Børglum, Anders D.; Bulik, Cynthia M.; Debost, Jean-Christophe Philippe Goldtsche; Grove, Jakob; Hougaard, David M.; McRae, Allan F.; Mors, Ole; Mortensen, Preben Bo; Musliner, Katherine L.; Nordentoft, Merete; Petersen, Liselotte V.; Privé, Florian; Sidorenko, Julia; Skogstrand, Kristin; Werge, Thomas; Wray, Naomi R.; Vilhjálmsson, Bjarni J.; McGrath, John J.
I: Cell Genomics, Bind 3, Nr. 12, 100457, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders
AU - Borbye-Lorenzen, Nis
AU - Zhu, Zhihong
AU - Agerbo, Esben
AU - Albiñana, Clara
AU - Benros, Michael E.
AU - Bian, Beilei
AU - Børglum, Anders D.
AU - Bulik, Cynthia M.
AU - Debost, Jean-Christophe Philippe Goldtsche
AU - Grove, Jakob
AU - Hougaard, David M.
AU - McRae, Allan F.
AU - Mors, Ole
AU - Mortensen, Preben Bo
AU - Musliner, Katherine L.
AU - Nordentoft, Merete
AU - Petersen, Liselotte V.
AU - Privé, Florian
AU - Sidorenko, Julia
AU - Skogstrand, Kristin
AU - Werge, Thomas
AU - Wray, Naomi R.
AU - Vilhjálmsson, Bjarni J.
AU - McGrath, John J.
N1 - © 2023 The Author(s).
PY - 2023
Y1 - 2023
N2 - Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.
AB - Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.
U2 - 10.1016/j.xgen.2023.100457
DO - 10.1016/j.xgen.2023.100457
M3 - Journal article
C2 - 38116117
VL - 3
JO - Cell Genomics
JF - Cell Genomics
SN - 2666-979x
IS - 12
M1 - 100457
ER -
ID: 377636476