The changing demographic pattern of multiple sclerosis epidemiology

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Standard

The changing demographic pattern of multiple sclerosis epidemiology. / Koch-Henriksen, Nils; Sørensen, Per Soelberg.

I: Lancet Neurology, Bind 9, Nr. 5, 01.05.2010, s. 520-32.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Koch-Henriksen, N & Sørensen, PS 2010, 'The changing demographic pattern of multiple sclerosis epidemiology', Lancet Neurology, bind 9, nr. 5, s. 520-32. https://doi.org/10.1016/S1474-4422(10)70064-8

APA

Koch-Henriksen, N., & Sørensen, P. S. (2010). The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurology, 9(5), 520-32. https://doi.org/10.1016/S1474-4422(10)70064-8

Vancouver

Koch-Henriksen N, Sørensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurology. 2010 maj 1;9(5):520-32. https://doi.org/10.1016/S1474-4422(10)70064-8

Author

Koch-Henriksen, Nils ; Sørensen, Per Soelberg. / The changing demographic pattern of multiple sclerosis epidemiology. I: Lancet Neurology. 2010 ; Bind 9, Nr. 5. s. 520-32.

Bibtex

@article{4d8411cf56594057993f5647d73f3534,

title = "The changing demographic pattern of multiple sclerosis epidemiology",

abstract = "The uneven distribution of multiple sclerosis (MS) across populations can be attributed to differences in genes and the environment and their interaction. Prevalence and incidence surveys could be affected by inaccuracy of diagnosis and ascertainment, and prevalence also depends on survival. These sources of error might play a part in the geographical and temporal variations. Our literature search and meta-regression analyses indicated an almost universal increase in prevalence and incidence of MS over time; they challenge the well accepted theory of a latitudinal gradient of incidence of MS in Europe and North America, while this gradient is still apparent for Australia and New Zealand; and suggest a general, although not ubiquitous, increase in incidence of MS in females. The latter observation should prompt epidemiological studies to focus on changes in lifestyle in females. New insights into gene-environment and gene-gene interactions complicate interpretations of demographic epidemiology and have made obsolete the idea of simple causative associations between genes or the environment and MS.",

author = "Nils Koch-Henriksen and S{\o}rensen, {Per Soelberg}",

year = "2010",

month = may,

day = "1",

doi = "http://dx.doi.org/10.1016/S1474-4422(10)70064-8",

language = "English",

volume = "9",

pages = "520--32",

journal = "The Lancet Neurology",

issn = "1474-4422",

publisher = "TheLancet Publishing Group",

number = "5",

}

RIS

TY - JOUR

T1 - The changing demographic pattern of multiple sclerosis epidemiology

AU - Koch-Henriksen, Nils

AU - Sørensen, Per Soelberg

PY - 2010/5/1

Y1 - 2010/5/1

N2 - The uneven distribution of multiple sclerosis (MS) across populations can be attributed to differences in genes and the environment and their interaction. Prevalence and incidence surveys could be affected by inaccuracy of diagnosis and ascertainment, and prevalence also depends on survival. These sources of error might play a part in the geographical and temporal variations. Our literature search and meta-regression analyses indicated an almost universal increase in prevalence and incidence of MS over time; they challenge the well accepted theory of a latitudinal gradient of incidence of MS in Europe and North America, while this gradient is still apparent for Australia and New Zealand; and suggest a general, although not ubiquitous, increase in incidence of MS in females. The latter observation should prompt epidemiological studies to focus on changes in lifestyle in females. New insights into gene-environment and gene-gene interactions complicate interpretations of demographic epidemiology and have made obsolete the idea of simple causative associations between genes or the environment and MS.

AB - The uneven distribution of multiple sclerosis (MS) across populations can be attributed to differences in genes and the environment and their interaction. Prevalence and incidence surveys could be affected by inaccuracy of diagnosis and ascertainment, and prevalence also depends on survival. These sources of error might play a part in the geographical and temporal variations. Our literature search and meta-regression analyses indicated an almost universal increase in prevalence and incidence of MS over time; they challenge the well accepted theory of a latitudinal gradient of incidence of MS in Europe and North America, while this gradient is still apparent for Australia and New Zealand; and suggest a general, although not ubiquitous, increase in incidence of MS in females. The latter observation should prompt epidemiological studies to focus on changes in lifestyle in females. New insights into gene-environment and gene-gene interactions complicate interpretations of demographic epidemiology and have made obsolete the idea of simple causative associations between genes or the environment and MS.

U2 - http://dx.doi.org/10.1016/S1474-4422(10)70064-8

DO - http://dx.doi.org/10.1016/S1474-4422(10)70064-8

M3 - Journal article

VL - 9

SP - 520

EP - 532

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 5

ER -

ID: 34093051