The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema
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The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. / Bjerring, Peter Nissen; Eefsen, Martin; Hansen, Bent Adel; Larsen, Fin Stolze.
I: Metabolic Brain Disease, Bind 24, Nr. 1, 2008, s. 5-14.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema
AU - Bjerring, Peter Nissen
AU - Eefsen, Martin
AU - Hansen, Bent Adel
AU - Larsen, Fin Stolze
N1 - Keywords: Ammonia; Animals; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Hyperammonemia; Intracranial Hypertension; Liver Failure, Acute; Mitochondria; Oxidative Stress; Water-Electrolyte Balance
PY - 2008
Y1 - 2008
N2 - Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure and circulatory collapse are frequent causes of death, but cerebral edema and intracranial hypertension (ICH) are also common complications with a high risk of fatal outcome. The underlying pathogenesis has been extensively studied and although the development of cerebral edema and ICH is of a complex and multifactorial nature, it is well established that ammonia plays a pivotal role. This review will focus on the effects of hyperammonemia on neurotransmission, mitochondrial function, oxidative stress, inflammation and regulation of cerebral blood flow. Finally, potential therapeutic targets and future perspectives are briefly discussed.
AB - Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure and circulatory collapse are frequent causes of death, but cerebral edema and intracranial hypertension (ICH) are also common complications with a high risk of fatal outcome. The underlying pathogenesis has been extensively studied and although the development of cerebral edema and ICH is of a complex and multifactorial nature, it is well established that ammonia plays a pivotal role. This review will focus on the effects of hyperammonemia on neurotransmission, mitochondrial function, oxidative stress, inflammation and regulation of cerebral blood flow. Finally, potential therapeutic targets and future perspectives are briefly discussed.
U2 - 10.1007/s11011-008-9116-3
DO - 10.1007/s11011-008-9116-3
M3 - Journal article
C2 - 19050999
VL - 24
SP - 5
EP - 14
JO - Metabolic Brain Disease
JF - Metabolic Brain Disease
SN - 0885-7490
IS - 1
ER -
ID: 20008910