The asbestos-asbestosis exposure-response relationship: a cohort study of the general working population
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The asbestos-asbestosis exposure-response relationship : a cohort study of the general working population. / Iversen, Inge Brosbøl; Vestergaard, Jesper Medom; Ohlander, Johan; Peters, Susan; Bendstrup, Elisabeth; Bonde, Jens Peter E.; Schlünssen, Vivi; Bønløkke, Jakob H.; Rasmussen, Finn; Stokholm, Zara A.; Andersen, Michael B.; Kromhout, Hans; Kolstad, Henrik A.
I: Scandinavian Journal of Work, Environment and Health, Bind 50, Nr. 5, 2024, s. 372-379.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The asbestos-asbestosis exposure-response relationship
T2 - a cohort study of the general working population
AU - Iversen, Inge Brosbøl
AU - Vestergaard, Jesper Medom
AU - Ohlander, Johan
AU - Peters, Susan
AU - Bendstrup, Elisabeth
AU - Bonde, Jens Peter E.
AU - Schlünssen, Vivi
AU - Bønløkke, Jakob H.
AU - Rasmussen, Finn
AU - Stokholm, Zara A.
AU - Andersen, Michael B.
AU - Kromhout, Hans
AU - Kolstad, Henrik A.
PY - 2024
Y1 - 2024
N2 - OBJECTIVES: The association between asbestos exposure and asbestosis in high-exposed industrial cohorts is well-known, but there is a lack of knowledge about the exposure-response relationship for asbestosis in a general working population setting. We examined the exposure-response relationship between occupational asbestos exposure and asbestosis in asbestos-exposed workers of the Danish general working population.METHODS: We followed all asbestos-exposed workers from 1979 to 2015 and identified incident cases of asbestosis using the Danish National Patient Register. Individual asbestos exposure was estimated with a quantitative job exposure matrix (SYN-JEM) from 1976 onwards and back-extrapolated to age 16 for those exposed in 1976. Exposure-response relations for cumulative exposure and other exposure metrics were analyzed using a discrete time hazard model and adjusted for potential confounders.RESULTS: The range of cumulative exposure in the population was 0.001 to 18 fibers per milliliter-year (f/ml-year). We found increasing incidence rate ratios (IRR) of asbestosis with increasing cumulative asbestos exposure with a fully adjusted IRR per 1 f/ml-years of 1.18 [95% confidence interval (CI) 1.15- -1.22]. The IRR was 1.94 (95% CI 1.53-2.47) in the highest compared to the lowest exposure tertile. We similarly observed increasing risk with increasing cumulative exposure in the inception population.CONCLUSIONS: This study found exposure-response relations between cumulative asbestos exposure and incident asbestosis in the Danish general working population with mainly low-level exposed occupations, but there is some uncertainty regarding the exposure levels.
AB - OBJECTIVES: The association between asbestos exposure and asbestosis in high-exposed industrial cohorts is well-known, but there is a lack of knowledge about the exposure-response relationship for asbestosis in a general working population setting. We examined the exposure-response relationship between occupational asbestos exposure and asbestosis in asbestos-exposed workers of the Danish general working population.METHODS: We followed all asbestos-exposed workers from 1979 to 2015 and identified incident cases of asbestosis using the Danish National Patient Register. Individual asbestos exposure was estimated with a quantitative job exposure matrix (SYN-JEM) from 1976 onwards and back-extrapolated to age 16 for those exposed in 1976. Exposure-response relations for cumulative exposure and other exposure metrics were analyzed using a discrete time hazard model and adjusted for potential confounders.RESULTS: The range of cumulative exposure in the population was 0.001 to 18 fibers per milliliter-year (f/ml-year). We found increasing incidence rate ratios (IRR) of asbestosis with increasing cumulative asbestos exposure with a fully adjusted IRR per 1 f/ml-years of 1.18 [95% confidence interval (CI) 1.15- -1.22]. The IRR was 1.94 (95% CI 1.53-2.47) in the highest compared to the lowest exposure tertile. We similarly observed increasing risk with increasing cumulative exposure in the inception population.CONCLUSIONS: This study found exposure-response relations between cumulative asbestos exposure and incident asbestosis in the Danish general working population with mainly low-level exposed occupations, but there is some uncertainty regarding the exposure levels.
U2 - 10.5271/sjweh.4153
DO - 10.5271/sjweh.4153
M3 - Journal article
C2 - 38577971
VL - 50
SP - 372
EP - 379
JO - Scandinavian journal of work, environment & health
JF - Scandinavian journal of work, environment & health
SN - 0355-3140
IS - 5
ER -
ID: 388996113