The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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The Anorexia Nervosa Genetics Initiative (ANGI) : Overview and methods. / Thornton, Laura M.; Munn-Chernoff, Melissa A.; Baker, Jessica H.; Juréus, Anders; Parker, Richard; Henders, Anjali K.; Larsen, Janne T.; Petersen, Liselotte; Watson, Hunna J.; Yilmaz, Zeynep; Kirk, Katherine M.; Gordon, Scott; Leppä, Virpi M.; Martin, Felicity C.; Whiteman, David C.; Olsen, Catherine M.; Werge, Thomas M.; Pedersen, Nancy L.; Kaye, Walter; Bergen, Andrew W.; Halmi, Katherine A.; Strober, Michael; Kaplan, Allan S.; Woodside, D. Blake; Mitchell, James; Johnson, Craig L.; Brandt, Harry; Crawford, Steven; Horwood, L. John; Boden, Joseph M.; Pearson, John F.; Duncan, Laramie E.; Grove, Jakob; Mattheisen, Manuel; Jordan, Jennifer; Kennedy, Martin A.; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Wade, Tracey D.; Montgomery, Grant W.; Martin, Nicholas G.; Landén, Mikael; Mortensen, Preben Bo; Sullivan, Patrick F.; Bulik, Cynthia M.
I: Contemporary Clinical Trials, Bind 74, 2018, s. 61-69.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The Anorexia Nervosa Genetics Initiative (ANGI)
T2 - Overview and methods
AU - Thornton, Laura M.
AU - Munn-Chernoff, Melissa A.
AU - Baker, Jessica H.
AU - Juréus, Anders
AU - Parker, Richard
AU - Henders, Anjali K.
AU - Larsen, Janne T.
AU - Petersen, Liselotte
AU - Watson, Hunna J.
AU - Yilmaz, Zeynep
AU - Kirk, Katherine M.
AU - Gordon, Scott
AU - Leppä, Virpi M.
AU - Martin, Felicity C.
AU - Whiteman, David C.
AU - Olsen, Catherine M.
AU - Werge, Thomas M.
AU - Pedersen, Nancy L.
AU - Kaye, Walter
AU - Bergen, Andrew W.
AU - Halmi, Katherine A.
AU - Strober, Michael
AU - Kaplan, Allan S.
AU - Woodside, D. Blake
AU - Mitchell, James
AU - Johnson, Craig L.
AU - Brandt, Harry
AU - Crawford, Steven
AU - Horwood, L. John
AU - Boden, Joseph M.
AU - Pearson, John F.
AU - Duncan, Laramie E.
AU - Grove, Jakob
AU - Mattheisen, Manuel
AU - Jordan, Jennifer
AU - Kennedy, Martin A.
AU - Birgegård, Andreas
AU - Lichtenstein, Paul
AU - Norring, Claes
AU - Wade, Tracey D.
AU - Montgomery, Grant W.
AU - Martin, Nicholas G.
AU - Landén, Mikael
AU - Mortensen, Preben Bo
AU - Sullivan, Patrick F.
AU - Bulik, Cynthia M.
PY - 2018
Y1 - 2018
N2 - Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.
AB - Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.
KW - Anorexia nervosa
KW - Eating disorders
KW - Genome-wide association
KW - Psychiatric genetics
KW - Psychiatric genomics consortium
KW - Social media
U2 - 10.1016/j.cct.2018.09.015
DO - 10.1016/j.cct.2018.09.015
M3 - Journal article
C2 - 30287268
AN - SCOPUS:85054436931
VL - 74
SP - 61
EP - 69
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
SN - 1551-7144
ER -
ID: 217394454