The AID-induced DNA damage response in chromatin

Forskning

The AID-induced DNA damage response in chromatin

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The AID-induced DNA damage response in chromatin. / Daniel, Jeremy A; Nussenzweig, André.

I: Molecular Cell, Bind 50, Nr. 3, 09.05.2013, s. 309-21.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Daniel, JA & Nussenzweig, A 2013, 'The AID-induced DNA damage response in chromatin', Molecular Cell, bind 50, nr. 3, s. 309-21. https://doi.org/10.1016/j.molcel.2013.04.017

APA

Daniel, J. A., & Nussenzweig, A. (2013). The AID-induced DNA damage response in chromatin. Molecular Cell, 50(3), 309-21. https://doi.org/10.1016/j.molcel.2013.04.017

Vancouver

Daniel JA, Nussenzweig A. The AID-induced DNA damage response in chromatin. Molecular Cell. 2013 maj 9;50(3):309-21. https://doi.org/10.1016/j.molcel.2013.04.017

Author

Daniel, Jeremy A ; Nussenzweig, André. / The AID-induced DNA damage response in chromatin. I: Molecular Cell. 2013 ; Bind 50, Nr. 3. s. 309-21.

Bibtex

@article{09e57f37f55e48d5bdc5bfd15e83575b,

title = "The AID-induced DNA damage response in chromatin",

abstract = "Chemical modifications to the DNA and histone protein components of chromatin can modulate gene expression and genome stability. Understanding the physiological impact of changes in chromatin structure remains an important question in biology. As one example, in order to generate antibody diversity with somatic hypermutation and class switch recombination, chromatin must be made accessible for activation-induced cytidine deaminase (AID)-mediated deamination of cytosines in DNA. These lesions are recognized and removed by various DNA repair pathways but, if not handled properly, can lead to formation of oncogenic chromosomal translocations. In this review, we focus the discussion on how chromatin-modifying activities and -binding proteins contribute to the native chromatin environment in which AID-induced DNA damage is targeted and repaired. Outstanding questions remain regarding the direct roles of histone posttranslational modifications and the significance of AID function outside of antibody diversity.",

author = "Daniel, {Jeremy A} and Andr{\'e} Nussenzweig",

year = "2013",

month = may,

day = "9",

doi = "10.1016/j.molcel.2013.04.017",

language = "English",

volume = "50",

pages = "309--21",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

RIS

TY - JOUR

T1 - The AID-induced DNA damage response in chromatin

AU - Daniel, Jeremy A

AU - Nussenzweig, André

PY - 2013/5/9

Y1 - 2013/5/9

N2 - Chemical modifications to the DNA and histone protein components of chromatin can modulate gene expression and genome stability. Understanding the physiological impact of changes in chromatin structure remains an important question in biology. As one example, in order to generate antibody diversity with somatic hypermutation and class switch recombination, chromatin must be made accessible for activation-induced cytidine deaminase (AID)-mediated deamination of cytosines in DNA. These lesions are recognized and removed by various DNA repair pathways but, if not handled properly, can lead to formation of oncogenic chromosomal translocations. In this review, we focus the discussion on how chromatin-modifying activities and -binding proteins contribute to the native chromatin environment in which AID-induced DNA damage is targeted and repaired. Outstanding questions remain regarding the direct roles of histone posttranslational modifications and the significance of AID function outside of antibody diversity.

AB - Chemical modifications to the DNA and histone protein components of chromatin can modulate gene expression and genome stability. Understanding the physiological impact of changes in chromatin structure remains an important question in biology. As one example, in order to generate antibody diversity with somatic hypermutation and class switch recombination, chromatin must be made accessible for activation-induced cytidine deaminase (AID)-mediated deamination of cytosines in DNA. These lesions are recognized and removed by various DNA repair pathways but, if not handled properly, can lead to formation of oncogenic chromosomal translocations. In this review, we focus the discussion on how chromatin-modifying activities and -binding proteins contribute to the native chromatin environment in which AID-induced DNA damage is targeted and repaired. Outstanding questions remain regarding the direct roles of histone posttranslational modifications and the significance of AID function outside of antibody diversity.

U2 - 10.1016/j.molcel.2013.04.017

DO - 10.1016/j.molcel.2013.04.017

M3 - Review

C2 - 23664375

VL - 50

SP - 309

EP - 321

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 3

ER -

ID: 47458909