The 5-HT1F receptor as the target of ditans in migraine — from bench to bedside

The 5-HT_1F receptor as the target of ditans in migraine — from bench to bedside

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The 5-HT_1F receptor as the target of ditans in migraine — from bench to bedside. / Mitsikostas, Dimos D.; Waeber, Christian; Sanchez-del-Rio, Margarita; Raffaelli, Bianca; Ashina, Håkan; Maassen van den Brink, Antoinette; Andreou, Anna; Pozo-Rosich, Patricia; Rapoport, Alan; Ashina, Messoud; Moskowitz, Michael A.

I: Nature Reviews Neurology, Bind 19, Nr. 8, 2023, s. 489-505.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Mitsikostas, DD, Waeber, C, Sanchez-del-Rio, M, Raffaelli, B, Ashina, H, Maassen van den Brink, A, Andreou, A, Pozo-Rosich, P, Rapoport, A, Ashina, M & Moskowitz, MA 2023, 'The 5-HT_1F receptor as the target of ditans in migraine — from bench to bedside', Nature Reviews Neurology, bind 19, nr. 8, s. 489-505. https://doi.org/10.1038/s41582-023-00842-x

APA

Mitsikostas, D. D., Waeber, C., Sanchez-del-Rio, M., Raffaelli, B., Ashina, H., Maassen van den Brink, A., Andreou, A., Pozo-Rosich, P., Rapoport, A., Ashina, M., & Moskowitz, M. A. (2023). The 5-HT_1F receptor as the target of ditans in migraine — from bench to bedside. Nature Reviews Neurology, 19(8), 489-505. https://doi.org/10.1038/s41582-023-00842-x

Vancouver

Mitsikostas DD, Waeber C, Sanchez-del-Rio M, Raffaelli B, Ashina H, Maassen van den Brink A o.a. The 5-HT_1F receptor as the target of ditans in migraine — from bench to bedside. Nature Reviews Neurology. 2023;19(8):489-505. https://doi.org/10.1038/s41582-023-00842-x

Author

Mitsikostas, Dimos D. ; Waeber, Christian ; Sanchez-del-Rio, Margarita ; Raffaelli, Bianca ; Ashina, Håkan ; Maassen van den Brink, Antoinette ; Andreou, Anna ; Pozo-Rosich, Patricia ; Rapoport, Alan ; Ashina, Messoud ; Moskowitz, Michael A. / The 5-HT_1F receptor as the target of ditans in migraine — from bench to bedside. I: Nature Reviews Neurology. 2023 ; Bind 19, Nr. 8. s. 489-505.

Bibtex

@article{344c260cbddf4996809c877a5c951102,

title = "The 5-HT1F receptor as the target of ditans in migraine — from bench to bedside",

abstract = "Migraine is a leading cause of disability in more than one billion people worldwide, yet it remains universally underappreciated, even by individuals with the condition. Among other shortcomings, current treatments (often repurposed agents) have limited efficacy and potential adverse effects, leading to low treatment adherence. After the introduction of agents that target the calcitonin gene-related peptide pathway, another new drug class, the ditans — a group of selective serotonin 5-HT1F receptor agonists — has just reached the international market. Here, we review preclinical studies from the late 1990s and more recent clinical research that contributed to the development of the ditans and led to their approval for acute migraine treatment by the US Food and Drug Administration and the European Medicines Agency.",

author = "Mitsikostas, {Dimos D.} and Christian Waeber and Margarita Sanchez-del-Rio and Bianca Raffaelli and H{\aa}kan Ashina and {Maassen van den Brink}, Antoinette and Anna Andreou and Patricia Pozo-Rosich and Alan Rapoport and Messoud Ashina and Moskowitz, {Michael A.}",

note = "Funding Information: The authors thank I. V. Barla for contributions to identifying the chemical composition and structure of ditans. Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",

year = "2023",

doi = "10.1038/s41582-023-00842-x",

language = "English",

volume = "19",

pages = "489--505",

journal = "Nature Reviews. Neurology",

issn = "1759-4758",

publisher = "nature publishing group",

number = "8",

}

RIS

TY - JOUR

T1 - The 5-HT1F receptor as the target of ditans in migraine — from bench to bedside

AU - Mitsikostas, Dimos D.

AU - Waeber, Christian

AU - Sanchez-del-Rio, Margarita

AU - Raffaelli, Bianca

AU - Ashina, Håkan

AU - Maassen van den Brink, Antoinette

AU - Andreou, Anna

AU - Pozo-Rosich, Patricia

AU - Rapoport, Alan

AU - Ashina, Messoud

AU - Moskowitz, Michael A.

PY - 2023

Y1 - 2023

N2 - Migraine is a leading cause of disability in more than one billion people worldwide, yet it remains universally underappreciated, even by individuals with the condition. Among other shortcomings, current treatments (often repurposed agents) have limited efficacy and potential adverse effects, leading to low treatment adherence. After the introduction of agents that target the calcitonin gene-related peptide pathway, another new drug class, the ditans — a group of selective serotonin 5-HT1F receptor agonists — has just reached the international market. Here, we review preclinical studies from the late 1990s and more recent clinical research that contributed to the development of the ditans and led to their approval for acute migraine treatment by the US Food and Drug Administration and the European Medicines Agency.

AB - Migraine is a leading cause of disability in more than one billion people worldwide, yet it remains universally underappreciated, even by individuals with the condition. Among other shortcomings, current treatments (often repurposed agents) have limited efficacy and potential adverse effects, leading to low treatment adherence. After the introduction of agents that target the calcitonin gene-related peptide pathway, another new drug class, the ditans — a group of selective serotonin 5-HT1F receptor agonists — has just reached the international market. Here, we review preclinical studies from the late 1990s and more recent clinical research that contributed to the development of the ditans and led to their approval for acute migraine treatment by the US Food and Drug Administration and the European Medicines Agency.

U2 - 10.1038/s41582-023-00842-x

DO - 10.1038/s41582-023-00842-x

M3 - Review

C2 - 37438431

AN - SCOPUS:85164456292

VL - 19

SP - 489

EP - 505

JO - Nature Reviews. Neurology

JF - Nature Reviews. Neurology

SN - 1759-4758

IS - 8

ER -

ID: 397756674