Tendinopathy

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Standard

Tendinopathy. / Millar, Neal L.; Silbernagel, Karin G.; Thorborg, Kristian; Kirwan, Paul D.; Galatz, Leesa M.; Abrams, Geoffrey D.; Murrell, George A.C.; McInnes, Iain B.; Rodeo, Scott A.

I: Nature Reviews Disease Primers, Bind 7, Nr. 1, 1, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Millar, NL, Silbernagel, KG, Thorborg, K, Kirwan, PD, Galatz, LM, Abrams, GD, Murrell, GAC, McInnes, IB & Rodeo, SA 2021, 'Tendinopathy', Nature Reviews Disease Primers, bind 7, nr. 1, 1. https://doi.org/10.1038/s41572-020-00234-1

APA

Millar, N. L., Silbernagel, K. G., Thorborg, K., Kirwan, P. D., Galatz, L. M., Abrams, G. D., Murrell, G. A. C., McInnes, I. B., & Rodeo, S. A. (2021). Tendinopathy. Nature Reviews Disease Primers, 7(1), [1]. https://doi.org/10.1038/s41572-020-00234-1

Vancouver

Millar NL, Silbernagel KG, Thorborg K, Kirwan PD, Galatz LM, Abrams GD o.a. Tendinopathy. Nature Reviews Disease Primers. 2021;7(1). 1. https://doi.org/10.1038/s41572-020-00234-1

Author

Millar, Neal L. ; Silbernagel, Karin G. ; Thorborg, Kristian ; Kirwan, Paul D. ; Galatz, Leesa M. ; Abrams, Geoffrey D. ; Murrell, George A.C. ; McInnes, Iain B. ; Rodeo, Scott A. / Tendinopathy. I: Nature Reviews Disease Primers. 2021 ; Bind 7, Nr. 1.

Bibtex

@article{c794d43a214f428399dda9a4ae8c5c91,
title = "Tendinopathy",
abstract = "Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.",
author = "Millar, {Neal L.} and Silbernagel, {Karin G.} and Kristian Thorborg and Kirwan, {Paul D.} and Galatz, {Leesa M.} and Abrams, {Geoffrey D.} and Murrell, {George A.C.} and McInnes, {Iain B.} and Rodeo, {Scott A.}",
year = "2021",
doi = "10.1038/s41572-020-00234-1",
language = "English",
volume = "7",
journal = "Nature Reviews. Disease Primers",
issn = "2056-676X",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Tendinopathy

AU - Millar, Neal L.

AU - Silbernagel, Karin G.

AU - Thorborg, Kristian

AU - Kirwan, Paul D.

AU - Galatz, Leesa M.

AU - Abrams, Geoffrey D.

AU - Murrell, George A.C.

AU - McInnes, Iain B.

AU - Rodeo, Scott A.

PY - 2021

Y1 - 2021

N2 - Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.

AB - Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse tendinopathies involve the rotator cuff tendon, medial and lateral elbow epicondyles, patellar tendon, gluteal tendons and the Achilles tendon. The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis. Although diagnosis is mostly achieved based on clinical symptoms, in some cases, additional pain-provoking tests and imaging might be necessary. Management consists of different exercise and loading programmes, therapeutic modalities and surgical interventions; however, their effectiveness remains ambiguous. Future research should focus on elucidating the key functional pathways implicated in clinical disease and on improved rehabilitation protocols.

U2 - 10.1038/s41572-020-00234-1

DO - 10.1038/s41572-020-00234-1

M3 - Journal article

C2 - 33414454

AN - SCOPUS:85098872279

VL - 7

JO - Nature Reviews. Disease Primers

JF - Nature Reviews. Disease Primers

SN - 2056-676X

IS - 1

M1 - 1

ER -

ID: 255350746