TY - JOUR

T1 - Temporal trends of hypertrophic cardiomyopathy in Denmark

T2 - a nationwide retrospective cohort study

AU - Zörner, Christopher Ryan

AU - Pallisgaard, Jannik

AU - Schjerning, Anne Marie

AU - Jensen, Morten Kvistholm

AU - Tønnesen, Jacob

AU - Da Riis-Vestergaard, Lise

AU - Middelfart, Charlotte

AU - Rasmussen, Peter Vibe

AU - Gislason, Gunnar

AU - Hansen, Morten Lock

N1 - Funding Information: Arguments to support the case for a bias in screening and detection between the genders can be found in this Danish cohort. There was an overweight of AF among males in this HCM cohort. Diagnosis with AF would, in accordance with current guidelines, result in the patient's referral to follow-up, including procedures such as echocardiography, in which previously unknown HCM would be more likely to be detected. With ever-increasing options for screening and follow-up for AF, this or comparable processes with other cardiovascular comorbidities could explain the difference in age and severity between the genders. However, more research is warranted to explain this disparity between the genders in HCM diagnosis sufficiently. Publisher Copyright: © 2023 Authors. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Objectives To describe the population of patients diagnosed with hypertrophic cardiomyopathy (HCM) in Denmark and determine temporal trends in incidence and patient characteristics over time. Design Nationwide retrospective cohort study. Setting Danish nationwide administrative and clinical registers and databases. Participants All patients aged ≥16 years diagnosed with HCM from 2005 to 2018. Outcomes measures Time trends in HCM diagnosis, patient characteristics, comorbidities and pharmacotherapy were identified and tested for significance using the Cochran-Armitage trend test. Results 3856 HCM patients were included (median age 68 years (IQR 56-78)). Although there were more males (53%), females were older (72 years vs 63 years) and more likely to have their type of HCM classified as obstructive (54% vs 38%). A consistent rise in HCM cases per year was detected and there was a significant decline in prevalence of heart failure (2005: 20% to 2018: 12%, p<0.001) and ischaemic heart disease (2005: 31% to 2019: 16%, p≤0.001). Prevalence of atrial fibrillation and stroke remained notable and unchanged. Lastly, the rate of hospitalisations decreased over time (2005: 64% to 2016: 46%, p<0.001), while the rate of outpatient follow-up increased (2005: 81% to 2016: 87%, p 0.003). Conclusion There was a consistent rise in HCM cases with decreasing morbidity burden. Females were older at diagnosis and more likely to have their type of HCM classified as obstructive. The rate of outpatient follow-up is increasing.

AB - Objectives To describe the population of patients diagnosed with hypertrophic cardiomyopathy (HCM) in Denmark and determine temporal trends in incidence and patient characteristics over time. Design Nationwide retrospective cohort study. Setting Danish nationwide administrative and clinical registers and databases. Participants All patients aged ≥16 years diagnosed with HCM from 2005 to 2018. Outcomes measures Time trends in HCM diagnosis, patient characteristics, comorbidities and pharmacotherapy were identified and tested for significance using the Cochran-Armitage trend test. Results 3856 HCM patients were included (median age 68 years (IQR 56-78)). Although there were more males (53%), females were older (72 years vs 63 years) and more likely to have their type of HCM classified as obstructive (54% vs 38%). A consistent rise in HCM cases per year was detected and there was a significant decline in prevalence of heart failure (2005: 20% to 2018: 12%, p<0.001) and ischaemic heart disease (2005: 31% to 2019: 16%, p≤0.001). Prevalence of atrial fibrillation and stroke remained notable and unchanged. Lastly, the rate of hospitalisations decreased over time (2005: 64% to 2016: 46%, p<0.001), while the rate of outpatient follow-up increased (2005: 81% to 2016: 87%, p 0.003). Conclusion There was a consistent rise in HCM cases with decreasing morbidity burden. Females were older at diagnosis and more likely to have their type of HCM classified as obstructive. The rate of outpatient follow-up is increasing.

KW - Adult cardiology

KW - Cardiac Epidemiology

KW - Cardiomyopathy

U2 - 10.1136/bmjopen-2023-074010

DO - 10.1136/bmjopen-2023-074010

M3 - Journal article

C2 - 37666552

AN - SCOPUS:85169848217

VL - 13

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 9

M1 - e074010

ER -