Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement
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Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement. / Del Val, David; Abdel-Wahab, Mohamed; Linke, Axel; Durand, Eric; Ihlemann, Nikolaj; Urena, Marina; Pellegrini, Costanza; Giannini, Francesco; Landt, Martin; Auffret, Vincent; Sinning, Jan Malte; Cheema, Asim; Nombela-Franco, Luis; Chamandi, Chekrallah; Campelo-Parada, Francisco; Munoz-Garcia, Antonio; Herrmann, Howard C.; Testa, Luca; Won-Keun, Kim; Castillo, Juan Carlos; Alperi, Alberto; Tchetche, Didier; Bartorelli, Antonio; Kapadia, Samir; Stortecky, Stefan; Amat-Santos, Ignacio; Wijeysundera, Harindra C.; Lisko, John; Gutiérrez-Ibanes, Enrique; Serra, Vicenç; Salido, Luisa; Alkhodair, Abdullah; Livi, Ugolino; Chakravarty, Tarun; Lerakis, Stamatios; Vilalta, Victoria; Regueiro, Ander; Romaguera, Rafael; Barbanti, Marco; Masson, Jean Bernard; Maes, Frédéric; Fiorina, Claudia; Miceli, Antonio; Kodali, Susheel; Ribeiro, Henrique B.; Mangione, Jose Armando; de Brito, Fabio Sandoli; Actis Dato, Guglielmo Mario; Rosato, Francesco; Ferreira, Maria Cristina; Lima, Valter Correa; Colafranceschi, Alexandre Siciliano; Abizaid, Alexandre; Marino, Marcos Antonio; Esteves, Vinicius; Andrea, Julio; Godinho, Roger R.; Eltchaninoff, Helene; Søndergaard, Lars; Himbert, Dominique; Husser, Oliver; Latib, Azeem; Le Breton, Hervé; Servoz, Clement; Pascual, Isaac; Siddiqui, Saif; Olivares, Paolo; Hernandez-Antolin, Rosana; Webb, John G.; Sponga, Sandro; Makkar, Raj; Kini, Annapoorna S.; Boukhris, Marouane; Mangner, Norman; Crusius, Lisa; Holzhey, David; Rodés-Cabau, Josep.
I: Clinical Infectious Diseases, Bind 73, Nr. 11, 2021, s. e3750-e3758.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement
AU - Del Val, David
AU - Abdel-Wahab, Mohamed
AU - Linke, Axel
AU - Durand, Eric
AU - Ihlemann, Nikolaj
AU - Urena, Marina
AU - Pellegrini, Costanza
AU - Giannini, Francesco
AU - Landt, Martin
AU - Auffret, Vincent
AU - Sinning, Jan Malte
AU - Cheema, Asim
AU - Nombela-Franco, Luis
AU - Chamandi, Chekrallah
AU - Campelo-Parada, Francisco
AU - Munoz-Garcia, Antonio
AU - Herrmann, Howard C.
AU - Testa, Luca
AU - Won-Keun, Kim
AU - Castillo, Juan Carlos
AU - Alperi, Alberto
AU - Tchetche, Didier
AU - Bartorelli, Antonio
AU - Kapadia, Samir
AU - Stortecky, Stefan
AU - Amat-Santos, Ignacio
AU - Wijeysundera, Harindra C.
AU - Lisko, John
AU - Gutiérrez-Ibanes, Enrique
AU - Serra, Vicenç
AU - Salido, Luisa
AU - Alkhodair, Abdullah
AU - Livi, Ugolino
AU - Chakravarty, Tarun
AU - Lerakis, Stamatios
AU - Vilalta, Victoria
AU - Regueiro, Ander
AU - Romaguera, Rafael
AU - Barbanti, Marco
AU - Masson, Jean Bernard
AU - Maes, Frédéric
AU - Fiorina, Claudia
AU - Miceli, Antonio
AU - Kodali, Susheel
AU - Ribeiro, Henrique B.
AU - Mangione, Jose Armando
AU - de Brito, Fabio Sandoli
AU - Actis Dato, Guglielmo Mario
AU - Rosato, Francesco
AU - Ferreira, Maria Cristina
AU - Lima, Valter Correa
AU - Colafranceschi, Alexandre Siciliano
AU - Abizaid, Alexandre
AU - Marino, Marcos Antonio
AU - Esteves, Vinicius
AU - Andrea, Julio
AU - Godinho, Roger R.
AU - Eltchaninoff, Helene
AU - Søndergaard, Lars
AU - Himbert, Dominique
AU - Husser, Oliver
AU - Latib, Azeem
AU - Le Breton, Hervé
AU - Servoz, Clement
AU - Pascual, Isaac
AU - Siddiqui, Saif
AU - Olivares, Paolo
AU - Hernandez-Antolin, Rosana
AU - Webb, John G.
AU - Sponga, Sandro
AU - Makkar, Raj
AU - Kini, Annapoorna S.
AU - Boukhris, Marouane
AU - Mangner, Norman
AU - Crusius, Lisa
AU - Holzhey, David
AU - Rodés-Cabau, Josep
N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Procedural improvements combined with the contemporary clinical profile of patients undergoing transcatheter aortic valve replacement (TAVR) may have influenced the incidence and outcomes of infective endocarditis (IE) following TAVR. We aimed to determine the temporal trends, characteristics, and outcomes of IE post-TAVR. METHODS: Observational study including 552 patients presenting definite IE post-TAVR. Patients were divided in 2 groups according to the timing of TAVR (historical cohort [HC]: before 2014; contemporary cohort [CC]: after 2014). RESULTS: Overall incidence rates of IE were similar in both cohorts (CC vs HC: 5.45 vs 6.52 per 1000 person-years; P = .12), but the rate of early IE was lower in the CC (2.29‰ vs 4.89‰, P < .001). Enterococci were the most frequent microorganism. Most patients presented complicated IE ( CC: 67.7%; HC: 69.6%; P = .66), but the rate of surgical treatment remained low (CC: 20.7%; HC: 17.3%; P = .32). The CC exhibited lower rates of in-hospital acute kidney injury (35.1% vs 44.6%; P = .036) and in-hospital (26.6% vs 36.4%; P = .016) and 1-year (37.8% vs 53.5%; P < .001) mortality. Higher logistic EuroScore, Staphylococcus aureus etiology, and complications (stroke, heart failure, and acute renal failure) were associated with in-hospital mortality in multivariable analyses (P < .05 for all). CONCLUSIONS: Although overall IE incidence has remained stable, the incidence of early IE has declined in recent years. The microorganism, high rate of complications, and very low rate of surgical treatment remained similar. In-hospital and 1-year mortality rates were high but progressively decreased over time.
AB - BACKGROUND: Procedural improvements combined with the contemporary clinical profile of patients undergoing transcatheter aortic valve replacement (TAVR) may have influenced the incidence and outcomes of infective endocarditis (IE) following TAVR. We aimed to determine the temporal trends, characteristics, and outcomes of IE post-TAVR. METHODS: Observational study including 552 patients presenting definite IE post-TAVR. Patients were divided in 2 groups according to the timing of TAVR (historical cohort [HC]: before 2014; contemporary cohort [CC]: after 2014). RESULTS: Overall incidence rates of IE were similar in both cohorts (CC vs HC: 5.45 vs 6.52 per 1000 person-years; P = .12), but the rate of early IE was lower in the CC (2.29‰ vs 4.89‰, P < .001). Enterococci were the most frequent microorganism. Most patients presented complicated IE ( CC: 67.7%; HC: 69.6%; P = .66), but the rate of surgical treatment remained low (CC: 20.7%; HC: 17.3%; P = .32). The CC exhibited lower rates of in-hospital acute kidney injury (35.1% vs 44.6%; P = .036) and in-hospital (26.6% vs 36.4%; P = .016) and 1-year (37.8% vs 53.5%; P < .001) mortality. Higher logistic EuroScore, Staphylococcus aureus etiology, and complications (stroke, heart failure, and acute renal failure) were associated with in-hospital mortality in multivariable analyses (P < .05 for all). CONCLUSIONS: Although overall IE incidence has remained stable, the incidence of early IE has declined in recent years. The microorganism, high rate of complications, and very low rate of surgical treatment remained similar. In-hospital and 1-year mortality rates were high but progressively decreased over time.
KW - infective endocarditis
KW - prosthetic valve endocarditis
KW - TAVR
KW - transcatheter aortic valve replacement
U2 - 10.1093/cid/ciaa1941
DO - 10.1093/cid/ciaa1941
M3 - Journal article
C2 - 33733675
AN - SCOPUS:85120864039
VL - 73
SP - e3750-e3758
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 11
ER -
ID: 304085347