Temporal changes of new-onset atrial fibrillation in patients randomized to surgical or transcatheter aortic valve replacement
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Temporal changes of new-onset atrial fibrillation in patients randomized to surgical or transcatheter aortic valve replacement. / Jørgensen, Troels Højsgaard; Thyregod, Hans Gustav Hørsted; Tarp, Julie Bjerre; Svendsen, Jesper Hastrup; Søndergaard, Lars.
I: International Journal of Cardiology, Bind 234, 2017, s. 16-21.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Temporal changes of new-onset atrial fibrillation in patients randomized to surgical or transcatheter aortic valve replacement
AU - Jørgensen, Troels Højsgaard
AU - Thyregod, Hans Gustav Hørsted
AU - Tarp, Julie Bjerre
AU - Svendsen, Jesper Hastrup
AU - Søndergaard, Lars
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Temporal development of new-onset atrial fibrillation (NOAF) after aortic valve replacement is unclear, and opportunistic screening has limited diagnostic accuracy. This is the first study to investigate the incidence and temporal development of NOAF detected by implantable loop recorder (ILR) in patients with aortic stenosis, randomized to surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR).METHOD: An ILR was implanted in a subgroup of patients without pre-procedural atrial fibrillation (AF), randomized to SAVR or TAVR in the NOTION trial. Data from the ILR were transmitted in intervals of 2weeks for 12weeks post-procedurally and analyzed.RESULTS: The study included 25 and 27 patients who underwent SAVR and TAVR, respectively. The cumulative rate of NOAF was 100% and 81.5% for patients undergoing SAVR and TAVR, respectively (P=0.06). TAVR patients without NOAF 6weeks post-procedurally remained free from NOAF. The prevalence of AF after SAVR decreased significantly after 8weeks when compared with the first 2weeks (50.0% vs. 84.0%, respectively; P<0.05). The prevalence of AF after TAVR did not change significantly during follow-up. The median AF burden (percentage of time with AF) was 2.8% and 0.04% during the first 2weeks after SAVR and TAVR, respectively (P=0.01) and it decreased significantly over time after SAVR but not after TAVR.CONCLUSION: NOAF subsided 6weeks after TAVR. AF prevalence and burden decreased significantly over time after SAVR, but remained stable after TAVR. These findings may be considered for post-procedural anti-coagulation strategy.
AB - BACKGROUND: Temporal development of new-onset atrial fibrillation (NOAF) after aortic valve replacement is unclear, and opportunistic screening has limited diagnostic accuracy. This is the first study to investigate the incidence and temporal development of NOAF detected by implantable loop recorder (ILR) in patients with aortic stenosis, randomized to surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR).METHOD: An ILR was implanted in a subgroup of patients without pre-procedural atrial fibrillation (AF), randomized to SAVR or TAVR in the NOTION trial. Data from the ILR were transmitted in intervals of 2weeks for 12weeks post-procedurally and analyzed.RESULTS: The study included 25 and 27 patients who underwent SAVR and TAVR, respectively. The cumulative rate of NOAF was 100% and 81.5% for patients undergoing SAVR and TAVR, respectively (P=0.06). TAVR patients without NOAF 6weeks post-procedurally remained free from NOAF. The prevalence of AF after SAVR decreased significantly after 8weeks when compared with the first 2weeks (50.0% vs. 84.0%, respectively; P<0.05). The prevalence of AF after TAVR did not change significantly during follow-up. The median AF burden (percentage of time with AF) was 2.8% and 0.04% during the first 2weeks after SAVR and TAVR, respectively (P=0.01) and it decreased significantly over time after SAVR but not after TAVR.CONCLUSION: NOAF subsided 6weeks after TAVR. AF prevalence and burden decreased significantly over time after SAVR, but remained stable after TAVR. These findings may be considered for post-procedural anti-coagulation strategy.
KW - Aged
KW - Aged, 80 and over
KW - Aortic Valve
KW - Aortic Valve Stenosis
KW - Atrial Fibrillation
KW - Female
KW - Heart Valve Prosthesis Implantation
KW - Humans
KW - Male
KW - Postoperative Complications
KW - Prevalence
KW - Risk Factors
KW - Severity of Illness Index
KW - Statistics as Topic
KW - Time Factors
KW - Transcatheter Aortic Valve Replacement
KW - Treatment Outcome
KW - Journal Article
KW - Randomized Controlled Trial
U2 - 10.1016/j.ijcard.2017.02.098
DO - 10.1016/j.ijcard.2017.02.098
M3 - Journal article
C2 - 28258844
VL - 234
SP - 16
EP - 21
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -
ID: 188159506